Skip to main content
Log in

Elektrolytstörungen in der Intensivmedizin

Electrolyte disorders in intensive care medicine

  • Leitthema
  • Published:
Die Nephrologie Aims and scope

Zusammenfassung

Elektrolytstörungen sind häufig in der Intensivmedizin und können Mortalität und Morbidität beeinflussen. Eine rasche Diagnostik ist für eine adäquate Therapie notwendig, darf allerdings im Einzelfall nicht die notwendige Korrektur der Elektrolytstörung verzögern. Die Hyponatriämie mit schweren Symptomen wie Krampfanfällen oder Koma sollte in der Regel durch Gabe von 3 % NaCl behandelt werden, weniger klinisch ausgeprägte Formen sollten zunächst diagnostisch beurteilt und dann spezifisch behandelt werden. Die Hypernatriämie tritt insbesondere in der Intensivmedizin häufig auf und sollte in Abhängigkeit von der Genese therapiert werden, da die Hypernatriämie mit einer erhöhten Mortalität einhergeht. Hyperkaliämie und Hypokaliämie müssen insbesondere wegen Herzrhythmusstörungen rasch erkannt und therapiert werden. Während die Hypophosphatämie auf der Normalstation eine untergeordnete Rolle spielt, muss sie auf der Intensivstation diagnostiziert und substituiert werden, da hierdurch die Mortalität gesenkt werden kann.

Abstract

Electrolyte disorders frequently occur in intensive care medicine and can influence mortality and morbidity. A rapid diagnostic evaluation is required for adequate treatment but in individual cases, this should not delay the necessary correction of the electrolyte disorder. Hyponatremia with severe symptoms, such as seizures or coma usually requires the administration of 3% NaCl, while less clinically severe forms should initially be diagnostically assessed and then be specifically treated. Hypernatremia occurs particularly frequently in intensive care medicine and should be treated based on the genesis as hypernatremia is associated with increased mortality. Hyperkalemia and hypokalemia should be rapidly diagnosed and treated given the increased risk of cardiac arrhythmia. While hypophosphatemia plays a subordinate role on normal wards, on the intensive care unit it must be diagnosed and subsequently substituted as this can reduce mortality.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1

Literatur

  1. Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D, Decaux G, Fenske W, Hoorn EJ, Ichai C, Joannidis M, Soupart A, Zietse R, Haller M, van der Veer S, Van Biesen W, Nagler E, Guideline Development Group (2014) Clinical practice guideline on diagnosis and treatment of hyponatraemia. Eur J Endocrinol 170:G1–G47

    Article  CAS  Google Scholar 

  2. Brouns SHA, Dortmans MKJ, Jonkers FS, Lambooij SLE, Kuijper A, Haak HR (2014) Hyponatraemia in elderly emergency department patients: a marker of frailty. Neth J Med 72:311–317

    CAS  Google Scholar 

  3. Adrogué HJ, Madias NE (2000) Hyponatremia. N Engl J Med 342:1581–1589. https://doi.org/10.1056/NEJM200005253422107

    Article  Google Scholar 

  4. Turchin A, Seifter JL, Seely EW (2003) Clinical problem-solving. Mind the gap. N Engl J Med 349:1465–1469

    Article  CAS  Google Scholar 

  5. Katz MA (1973) Hyperglycemia-induced hyponatremia—calculation of expected serum sodium depression. N Engl J Med 289:843–844

    Article  CAS  Google Scholar 

  6. Sterns RH (2015) Disorders of plasma sodium. N Engl J Med 372:1269

    Article  Google Scholar 

  7. Verbalis JG, Goldsmith SR, Greenberg A, Korzelius C, Schrier RW, Sterns RH, Thompson CJ (2013) Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations. Am J Med 126:S1–S42

    Article  Google Scholar 

  8. Adrogué HJ, Madias NE (2000) Hypernatremia. N Engl J Med 342:1493–1499

    Article  Google Scholar 

  9. Sterns RH, Silver SM (2003) Salt and water: read the package insert. QJM 96:549–552

    Article  CAS  Google Scholar 

  10. Chauhan K, Pattharanitima P, Patel N, Duffy A, Saha A, Chaudhary K, Debnath N, Van Vleck T, Chan L, Nadkarni GN, Coca SG (2019) Rate of correction of hypernatremia and health outcomes in critically ill patients. Clin J Am Soc Nephrol 14:656–663

    Article  CAS  Google Scholar 

  11. Kardalas E, Paschou SA, Anagnostis P, Muscogiuri G, Siasos G, Vryonidou A (2018) Hypokalemia: a clinical update. Endocr Connect 7:R135–R146

    Article  CAS  Google Scholar 

  12. McDonough AA, Youn JH (2017) Potassium homeostasis: the knowns, the unknowns, and the health benefits. Comp Biochem Physiol A Physiol 32:100–111

    CAS  Google Scholar 

  13. Gumz ML, Rabinowitz L, Wingo CS (2015) An integrated view of potassium homeostasis. N Engl J Med 373:60–72

    Article  CAS  Google Scholar 

  14. Rengarajan S, Lee DH, Oh YT, Delpire E, Youn JH, McDonough AA (2014) Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis. Am J Physiol Renal Physiol 306:F1059–F1068

    Article  CAS  Google Scholar 

  15. Huang C, Kuo E (2007) Mechanism of hypokalemia in magnesium deficiency. J Am Soc Nephrol 18:2649–2652

    Article  Google Scholar 

  16. Hougen I, Leon SJ, Whitlock R, Rigatto C, Komenda P, Bohm C, Tangri N (2021) Hyperkalemia and its association with mortality, cardiovascular events, hospitalizations, and intensive care unit admissions in a population-based retrospective cohort. Kidney Int Rep 6:1309–1316

    Article  Google Scholar 

  17. Regolisti G, Maggiore U, Greco P, Maccari C, Parenti E, Di Mario F, Pistolesi V, Morabito S, Fiaccadori E (2020) Electrocardiographic T wave alterations and prediction of hyperkalemia in patients with acute kidney injury. Intern Emerg Med 15:463–472

    Article  Google Scholar 

  18. Palmer BF, Carrero JJ, Clegg DJ, Colbert GB, Emmett M, Fishbane S, Hain DJ, Lerma E, Onuigbo M, Rastogi A, Roger SD, Spinowitz BS, Weir MR (2021) Clinical management of hyperkalemia. Mayo Clin Proc 96:744–762

    Article  CAS  Google Scholar 

  19. Humphrey TJL, James G, Wilkinson IB, Hiemstra TF (2022) Clinical outcomes associated with the emergency treatment of hyperkalaemia with intravenous insulin-dextrose. Eur J Intern Med 95:87–92

    Article  CAS  Google Scholar 

  20. Peacock WF, Rafique Z, Clark CL, Singer AJ, Turner S, Miller J, Char D, Lagina A, Smith LM, Blomkalns AL, Caterino JM, Kosiborod M, REVEAL-ED Study Investigators (2018) Real world evidence for treatment of Hyperkalemia in the emergency department (REVEAL-ED): a multicenter, prospective, observational study. J Emerg Med 55:741–750

    Article  Google Scholar 

  21. Di Palo KE, Sinnett MJ, Goriacko P (2022) Assessment of patiromer monotherapy for Hyperkalemia in an acute care setting. JAMA Netw Open 5:e2145236

    Article  Google Scholar 

  22. Toporek AH, Semler MW, Self WH, Bernard GR, Wang L, Siew ED, Stollings JL, Wanderer JP, Rice TW, Casey JD, SMART Investigators and the Pragmatic Critical Care Research Group (2021) Balanced crystalloids versus saline in critically ill adults with Hyperkalemia or acute kidney injury: secondary analysis of a clinical trial. Am J Respir Crit Care Med 203:1322–1325

    Article  Google Scholar 

  23. Dhatariya KK, Joint British Diabetes Societies for Inpatient Care (2022) The management of diabetic ketoacidosis in adults—An updated guideline from the Joint British Diabetes Society for Inpatient Care. Diabet Med 39:e14788

    Article  Google Scholar 

  24. Soliman HM, Mercan D, Lobo SSM, Mélot C, Vincent J (2003) Development of ionized hypomagnesemia is associated with higher mortality rates. Crit Care Med 31:1082–1087

    Article  CAS  Google Scholar 

  25. Ryzen E, Elbaum N, Singer FR, Rude RK (1985) Parenteral magnesium tolerance testing in the evaluation of magnesium deficiency. Magnesium 4:137–147

    CAS  Google Scholar 

  26. Jiang P, Lv Q, Lai T, Xu F (2017) Does hypomagnesemia impact on the outcome of patients admitted to the intensive care unit? A systematic review and meta-analysis. Shock 47:288–295

    Article  CAS  Google Scholar 

  27. Hansen B, Bruserud Ø (2018) Hypomagnesemia in critically ill patients. J Intensive Care 6:21. https://doi.org/10.1186/s40560-018-0291-y

    Article  Google Scholar 

  28. RENAL Replacement Therapy Study Investigators, Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lo S, McArthur C, McGuinness S, Myburgh J, Norton R, Scheinkestel C, Su S (2009) Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med 361:1627–1638

    Article  Google Scholar 

  29. da Silva JSV, Seres DS, Sabino K, Adams SC, Berdahl GJ, Citty SW, Cober MP, Evans DC, Greaves JR, Gura KM, Michalski A, Plogsted S, Sacks GS, Tucker AM, Worthington P, Walker RN, Ayers P, Parenteral Nutrition Safety and Clinical Practice Committees, American Society for Parenteral and Enteral Nutrition (2020) ASPEN consensus recommendations for Refeeding syndrome. Nutr Clin Pract 35:178–195

    Article  Google Scholar 

  30. Doig GS, Simpson F, Heighes PT, Bellomo R, Chesher D, Caterson ID, Reade MC, Harrigan PWJ, Refeeding Syndrome Trial Investigators Group (2015) Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. Lancet Respir Med 3:943–952

    Article  Google Scholar 

  31. Thompson Bastin ML, Stromberg AJ, Nerusu SN, Liu LJ, Mayer KP, Liu KD, Bagshaw SM, Wald R, Morris PE, Neyra JA (2022) Association of phosphate-containing versus phosphate-free solutions on ventilator days in patients requiring continuous kidney replacement therapy. Clin J Am Soc Nephrol 17:634–642

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Heiko Schenk.

Ethics declarations

Interessenkonflikt

H. Schenk, K.M. Schmidt-Ott und J.J. Schmidt geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

Additional information

Redaktion

Thorsten Feldkamp, Rendsburg-Eckernförde

Oliver Witzke, Essen

figure qr

QR-Code scannen & Beitrag online lesen

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schenk, H., Schmidt-Ott, K.M. & Schmidt, J.J. Elektrolytstörungen in der Intensivmedizin. Nephrologie 18, 7–13 (2023). https://doi.org/10.1007/s11560-022-00619-1

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11560-022-00619-1

Schlüsselwörter

Keywords

Navigation