Skip to main content

Advertisement

Log in

Automatic generation of anatomic characteristics from cerebral aneurysm surface models

  • Original Article
  • Published:
International Journal of Computer Assisted Radiology and Surgery Aims and scope Submit manuscript

Abstract

Purpose

Computer-aided research on cerebral aneurysms often depends on a polygonal mesh representation of the vessel lumen. To support a differentiated, anatomy-aware analysis, it is necessary to derive anatomic descriptors from the surface model. We present an approach on automatic decomposition of the adjacent vessels into near- and far-vessel regions and computation of the axial plane. We also exemplarily present two applications of the geometric descriptors: automatic computation of a unique vessel order and automatic viewpoint selection.

Methods

Approximation methods are employed to analyze vessel cross-sections and the vessel area profile along the centerline. The resulting transition zones between near- and far- vessel regions are used as input for an optimization process to compute the axial plane. The unique vessel order is defined via projection into the plane space of the axial plane. The viewing direction for the automatic viewpoint selection is derived from the normal vector of the axial plane.

Results

The approach was successfully applied to representative data sets exhibiting a broad variability with respect to the configuration of their adjacent vessels. A robustness analysis showed that the automatic decomposition is stable against noise. A survey with 4 medical experts showed a broad agreement with the automatically defined transition zones.

Conclusion

Due to the general nature of the underlying algorithms, this approach is applicable to most of the likely aneurysm configurations in the cerebral vasculature. Additional geometric information obtained during automatic decomposition can support correction in case the automatic approach fails. The resulting descriptors can be used for various applications in the field of visualization, exploration and analysis of cerebral aneurysms.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Parlea L, Fahriga R, Holdsworth DW, Lowniea SP (1999) An analysis of the geometry of saccular intracranial aneurysms. Neuroradiology 20: 1079–1089

    CAS  Google Scholar 

  2. Cebral R, Castro MA, Burgess JE et al (2005) Characterization of cerebral aneurysms for assessing risk of rupture by using patient-specific computational hemodynamics models. Neuroradiology 26: 2550–2559

    Google Scholar 

  3. Seshadhri S, Gabor J, Beuing O, Skalej M, Thevenin D (2011) Impact of stents and flow diverters on hemodynamics in idealized aneurysm models. Biomech Eng 133: 071005

    Article  Google Scholar 

  4. Larrabide I, Omedas P, Martelli Y et al (2009) GIMIAS: an open source framework for efficient development of research tools and clinical prototypes. Funct Imaging Model Heart 5528: 417–426

    Article  Google Scholar 

  5. Kuhn A, Lehmann DJ, Gaststeiger R et al (2011) A clustering-based visualization technique to emphasize meaningful regions of vector fields. In: Proceedings of 16th international workshop on vision, modeling and visualization (VMV), pp 191–198

  6. Antiga L, Piccinelli M, Botti L et al (2008) An image-based modelling framework for patient-specific computational hemodynamics. Med Biol Eng Comput 46: 1097–1112

    Article  PubMed  Google Scholar 

  7. Piccinelli M, Veneziani A, Steinman DA et al (2009) A framework for geometric analysis of vascular structures: application to cerebral aneurysms. Trans Med Imaging 28: 1141–1155

    Article  Google Scholar 

  8. Ma B, Harbaugh RE, Raghavan ML (2004) Three-dimensional geometrical characterization of cerebral aneurysms. Ann Biomed Eng 32: 264–273

    Article  PubMed  Google Scholar 

  9. Sgouritsa E, Mohamed A, Morsi H et al (2010) Neck localization and geometry quantification of intracranial aneurysms. Proc IEEE Biomed Imaging, pp 1057–1060

  10. Neugebauer M, Diehl V, Skalej M, Preim B (2010) Geometric reconstruction of the ostium of cerebral aneurysms. In: Proceedings of 15th international workshop on vision, modeling and visualization (VMV), pp 307–314

  11. Tateshima S, Chien A, Sayre J et al (2010) The effect of aneurysm geometry on the intra-aneurysmal flow conditions. Neuroradiology 52: 1135–1141

    Article  PubMed  Google Scholar 

  12. Mantha A, Benndorf G, Hernandez A, Metcalfe R (2009) Stability of pulsatile blood flow at the ostiumof cerebral aneurysms. J Biomech 42: 1081–1087

    Article  PubMed  Google Scholar 

  13. Baharoglu M, Schirmer C, Hoit D et al (2010) Aneurysm inflow-angle as a discriminant for rupture in sidewall cerebral aneurysms: morphometric and computational fluid dynamic analysis. Stroke 7: 1423–1430

    Article  Google Scholar 

  14. Cebral JR, Muta F, Weir J, Putman C (2011) Quantitative characterization of the hemodynamic environment in ruptured and unruptured brain aneurysms. Neuroradiology 32: 145–151

    Article  CAS  Google Scholar 

  15. Lesage D, Angelini ED, Bloch I, Funka-Lea G (2009) A review of 3D vessel lumen segmentation techniques: models, features and extraction schemes. Med Image Anal 13: 819–845

    Article  PubMed  Google Scholar 

  16. Bogunovic H, Pozo JM, Villa-Uriol MC et al (2011) Automated segmentation of cerebral vasculature with aneurysms in 3DRA and TOF-MRA using geodesic active regions: an evaluation study. Med Phys 38: 210–219

    Article  PubMed  Google Scholar 

  17. Sen Y, Qian Y, Zhang Y, Morgan M (2011) A comparison of medical image segmentation methods for cerebral aneurysm computational hemodynamics. BMEI 2: 901–904

    Google Scholar 

  18. Mönch T, Neugebauer M, Preim B (2011) Optimization of vascular surface models for computational fluid dynamics and rapid prototyping. Second Int Workshop Digit Eng, pp 16–23

  19. Schöberl J (1977) NETGEN: an advancing front 2D/3D mesh generator based on abstract rules. Comput Vis Sci 1: 41–52

    Google Scholar 

  20. Neugebauer M, Preim B (2011) Generation of a smooth ostium surface for aneurysm surface models. In: Proceedings of bildverarbeitung für die medizin (BVM), pp 399–403

  21. Forbes A (1990) Least squares best-fit geometric elements. Algorithms Approx II 1988: 311–319

    Google Scholar 

  22. Mühler K, Neugebauer M, Tietjen C, Preim B (2007) Viewpoint selection for intervention planning. EuroVis, pp 267–274

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to M. Neugebauer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Neugebauer, M., Lawonn, K., Beuing, O. et al. Automatic generation of anatomic characteristics from cerebral aneurysm surface models. Int J CARS 8, 279–289 (2013). https://doi.org/10.1007/s11548-012-0779-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11548-012-0779-1

Keywords

Navigation