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Unambiguous radiologic extranodal extension determined by MRI could be a biomarker in predicting metastatic prostate cancer

  • Abdominal Radiology
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La radiologia medica Aims and scope Submit manuscript

Abstract

Objective

To explore the relationship between unambiguous radiologic extranodal extension (rENE) and M1 staging in patients with metastatic PCa.

Methods

A respective analysis of 1073 patients of PCa N1 staging from January 2004 to May 2022 was retrospectively enrolled. They were divided into rENE + and rENE −  groups and retrospectively analyzed the M staging with nuclear medicine data. The correlation index between unambiguous rENE and M1b staging was calculated. Logistic regression was used to evaluate the predictive performance of unambiguous rENE in M1b staging. ROC curves were used to investigate the relationship between unambiguous rENE and M staging in patients who underwent 68 Ga-PSMA PET/CT.

Results

A total of 1073 patients were included. Seven hundred and eighty patients were classified into the rENE + group (mean age, 69.6 years ± 8.7 [standard deviation]), and 293 were classified into rENE −  group (mean age, 66.7 years ± 9.4 [standard deviation]). Relationship between unambiguous rENE and M1b existed (r = 0.58, 95%CI: 0.52–0.64, P < 0.05). Unambiguous rENE could be an independent predictor for M1b (OR = 13.64, 95%CI: 9.23–20.14, P < 0.05). The AUC of unambiguous rENE in predicting M1b and M staging was 0.835 and 0.915, respectively, in patients who underwent 68 Ga-PSMA PET/CT.

Conclusions

Unambiguous rENE could be a strong biomarker to predict M1b and M staging in patients with PCa. When rENE came up, patients should perform nuclear medicine immediately, and a systematic treatment should be considered.

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Funding

The Natural Science Basic Research Program of Shaanxi Province, China (2021JZ-25). The National Natural Science Foundation of China (No. 82220108004). The Science and technology Innovation team of Shaanxi Province, China (2021TD-39)

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Authors and Affiliations

  1. Department of Radiology, Xijing Hospital, Air Force Medical University, 127 Chang Le West Road, Xi’an, Shaanxi Province, China

    Ye Han, Fan Shen, Zunjian Xiao, Jing Ren & Yi Huan

  2. Department of Urology, Xijing Hospital, Air Force Medical University, 127 Chang Le West Road, Xi’an, Shaanxi Province, China

    Jianhua Jiao & Weijun Qin

  3. Department of Radiology, 83 Group Military Hospital of People’s Liberation Army, Xiangyang Road No.371, Xinxiang, Henan Province, China

    Ye Han

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  1. Ye Han
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Correspondence to Jing Ren.

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Han, Y., Shen, F., Jiao, J. et al. Unambiguous radiologic extranodal extension determined by MRI could be a biomarker in predicting metastatic prostate cancer. Radiol med 128, 520–527 (2023). https://doi.org/10.1007/s11547-023-01631-8

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