Abstract
CT urography is a single term used to refer to different scanning protocols that can be applied for a number of clinical indications. If, on the one hand, this highlights the role of the radiologist in deciding the most suitable technique to perform according to the patient’s needs, on the other hand, a certain confusion may arise due to the different technical and clinical variables that have to be taken into account. This has been well demonstrated by a previous work based on an online questionnaire administered to a population of Italian radiologists that brought out similarities as well as differences across the national country. Defining precise guidelines for each clinical scenario, although desirable, is a difficult task to accomplish, if not even unfeasible. According to the prementioned survey, five relevant topics concerning CT urography have been identified: definition and clinical indications, opacification of the excretory system, techniques, post-processing reconstructions, and radiation dose and utility of dual-energy CT. The aim of this work is to deepen and share knowledge about these main points in order to assist the radiology in the daily practice. Moreover, a synopsis of recommendations agreed by the Italian board of genitourinary imaging is provided.
Similar content being viewed by others
References
Cheng K, Cassidy F, Aganovic L, Taddonio M, Vahdat N (2019) CT urography: how to optimize the technique. Abdom Radiol 44(12):3786–3799. https://doi.org/10.1007/s00261-019-02111-2. (PMID: 31317210)
Ascenti G, Cicero G, Bertelli E, Papa M, Gentili F, Ciccone V, Manetta R, Gandolfo N, Cardone G, Miele V (2022) CT-urography: a nationwide survey by the Italian board of urogenital radiology. Radiol Med 127(6):577–588. https://doi.org/10.1007/s11547-022-01488-3. (Epub 2022 Apr 5 PMID: 35381905)
Van Der Molen AJ, Cowan NC, Mueller-Lisse UG, Nolte-Ernsting CC, Takahashi S, Cohan RH (2008) CT urography working group of the european society of urogenital radiology (ESUR). CT urography: definition, indications and techniques. A guideline for clinical practice. Eur Radiol 18(1):4–17. https://doi.org/10.1007/s00330-007-0792-x. (Epub 2007 Nov 1 PMID: 17973110)
Shaish H, Newhouse JH (2017) Split-bolus CT urogram: Is less more? Abdom Radiol 42(8):2119–2126. https://doi.org/10.1007/s00261-017-1098-3. (PMID: 28271274)
Jemal A, Siegel R, Ward E et al (2007) Cancer statistics. CA Cancer J Clin 57(1):43–66
Froemming A, Potretzke T, Takahashi N, Kim B (2018) Upper tract urothelial cancer. Eur J Radiol 98:50–60. https://doi.org/10.1016/j.ejrad.2017.10.021. (Epub 2017 Nov 8 PMID: 29279170)
Assimos D, Krambeck A, Miller NL et al (2016) Surgical management of stones: American urological association/endourological society guideline, part II. J Urol 196:1161
Haroon SA, Rahimi H, Merritt A, Baghdanian A, Baghdanian A, LeBedis CA (2019) Computed tomography (CT) in the evaluation of bladder and ureteral trauma: indications, technique, and diagnosis. Abdom Radiol 44(12):3962–3977. https://doi.org/10.1007/s00261-019-02161-6. (PMID: 31494707)
Fouladi DF, Shayesteh S, Fishman EK, Chu LC (2020) Imaging of urinary bladder injury: the role of CT cystography. Emerg Radiol 27(1):87–95. https://doi.org/10.1007/s10140-019-01739-3. (Epub 2019 Nov 15 PMID: 31729629)
Kim JK, Park SY, Kim HJ, Kim CS, Ahn HJ, Ahn TY, Cho KS (2003) Living donor kidneys: usefulness of multi-detector row CT for comprehensive evaluation. Radiology 229(3):869–876. https://doi.org/10.1148/radiol.2293021098. (Epub 2003 Oct 30 PMID: 14593192)
Sebastià C, Peri L, Salvador R, Buñesch L, Revuelta I, Alcaraz A, Nicolau C (2010) Multidetector CT of living renal donors: lessons learned from surgeons. Radiographics 30(7):1875–1890. https://doi.org/10.1148/rg.307105032. (PMID: 21057125)
Krishnan V, Chawla A, Sharbidre KG, Peh WCG (2018) Current techniques and clinical applications of computed tomography urography. Curr Probl Diagn Radiol 47(4):245–256. https://doi.org/10.1067/j.cpradiol.2017.07.002. (Epub 2017 Jul 8 PMID: 28774661)
Kemper J, Regier M, Stork A, Adam G, Nolte-Ernsting C (2006) Improved visualization of the urinary tract in multidetector CT urography (MDCTU): analysis of individual acquisition delay and opacification using furosemide and low-dose test images. J Comput Assist Tomogr 30(5):751–7. https://doi.org/10.1097/01.rct.0000224631.25198.ed. (PMID: 16954923)
Raman SP, Fishman EK (2017) Upper and lower tract urothelial imaging using computed tomography urography. Radiol Clin North Am 55(2):225–241. https://doi.org/10.1016/j.rcl.2016.10.008. (Epub 2016 Nov 7 PMID: 28126213)
Renard-Penna R, Rocher L, Roy C, André M, Bellin MF, Boulay I, Eiss D, Girouin N, Grenier N, Hélénon O, Lapray JF, Lefèvre A, Matillon X, Ménager JM, Millet I, Ronze S, Sanzalone T, Tourniaire J, Brunelle S, Rouvière O, French Society of Genitourinary Imaging Consensus group (2020) Imaging protocols for CT urography: results of a consensus conference from the French Society of Genitourinary Imaging. EurRadiol. 30(3):1387–1396. https://doi.org/10.1007/s00330-019-06529-6. (Epub 2019 Dec 17. PMID: 31848742)
Ljungberg A, Segelsjö M, Dahlman P, Helenius M, Magnusson M, Magnusson A (2021) Comparison of quality of urinary bladder filling in CT urography with different doses of furosemide in the work-up of patients with macroscopic hematuria. Radiography 27(1):136–141. https://doi.org/10.1016/j.radi.2020.07.002. (Epub 2020 Jul 26 PMID: 32727709)
Silverman SG, Akbar SA, Mortele KJ, Tuncali K, Bhagwat JG, Seifter JL (2006) Multi-detector row CT urography of normal urinary collecting system: furosemide versus saline as adjunct to contrast medium. Radiology 240(3):749–755. https://doi.org/10.1148/radiol.2403050233. (PMID: 16926326)
Maheshwari E, O’Malley ME, Ghai S, Staunton M, Massey C (2010) Split-bolus MDCT urography: Upper tract opacification and performance for upper tract tumors in patients with hematuria. AJR Am J Roentgenol 194(2):453–458. https://doi.org/10.2214/AJR.09.3228. (PMID: 20093609)
Caoili EM, Inampudi P, Cohan RH, Ellis JH (2005) Optimization of multi-detector row CT urography: effect of compression, saline administration, and prolongation of acquisition delay. Radiology 235(1):116–123. https://doi.org/10.1148/radiol.2351031085. (Epub 2005 Feb 16 PMID: 15716388)
Lee D, Cho ES, Kim JH, Kim YP, Lee HK, Yu JS, Chung JJ (2017) Optimization of split-bolus CT urography: effect of differences in allocation of contrast medium and prolongation of imaging delay. AJR Am J Roentgenol 209(1):W10–W17. https://doi.org/10.2214/AJR.16.16459. (Epub 2017 May 2 PMID: 28463522)
Kupershmidt M, Margolis M, Jang H-J, Massey C, Metser U (2011) Evaluation of upper urinary tract tumors with portal venous phase MDCT: a case-control study. Am J Roentgenol 197:424–428
Metser U, Goldstein MA, Chawla TP, Fleshner NE, Jacks LM, O’Malley ME (2012) Detection of urothelial tumors: comparison of urothelial phase with excretory phase CT urography—a prospective study. Radiology 264:110–118
Kemper J, Regier M, Stork A, Adam G, Nolte-ernsting C (2006) Improved visualization of the urinary tract in multidetector Ct urography (mdctu): analysis of individual acquisition delay and opacification using furosemide and low-dose test images. J Comput Assist Tomogr 30:751–757
Abuhasanein S, Hansen C, Vojinovic D, Jahnson S, Leonhardt H, Kjölhede H (2022) Computed tomography urography with corticomedullary phase can exclude urinary bladder cancer with high accuracy. BMC Urol 22(1):60. https://doi.org/10.1186/s12894-022-01009-4. (PMID:35413901;PMCID:PMC9006563)
Helenius M, Dahlman P, Lonnemark M, Brekkan E, Wernroth L, Magnusson A (2016) Comparison of post contrast CT urography phases in bladder cancer detection. Eur Radiol 26(2):585–591. https://doi.org/10.1007/s00330-015-3844-7. (Epub 2015 May 24 PMID: 26002135)
Kekelidze M, Dwarkasing RS, Dijkshoorn ML, Sikorska K, Verhagen PC, Krestin GP (2010) Kidney and urinary tract imaging: triple-bolus multidetector CT urography as a one-stop shop–protocol design, opacification, and image quality analysis. Radiology 255(2):508–516. https://doi.org/10.1148/radiol.09082074. (Epub 2010 Feb 16 PMID: 20160002)
Ali O, Fishman EK, Sheth S (2019) Upper urinary tract urothelial carcinoma on multidetector CT: spectrum of disease. Abdom Radiol 44(12):3874–3885. https://doi.org/10.1007/s00261-019-02173-2. (Erratum.In:AbdomRadiol(NY).2019Nov14; PMID: 31440804)
Yecies T, Bandari J, Fam M, Macleod L, Jacobs B, Davies B (2018) Risk of radiation from computerized tomography urography in the evaluation of asymptomatic microscopic hematuria. J Urol 200(5):967–972. https://doi.org/10.1016/j.juro.2018.05.118. (Epub 2018 May 30 PMID: 29857078)
Martingano P, Cavallaro MFM, Bozzato AM, Baratella E, Cova MA (2020) CT urography findings of upper urinary tract carcinoma and its mimickers: a pictorial review. Medicina 56(12):705. https://doi.org/10.3390/medicina56120705. (PMID:33348865;PMCID:PMC7766367)
Wang LJ, Wong YC, Hwang YS, Pang ST, Chuang CK, Chang YH (2021) Split-bolus computed tomography urography (CTU) achieves more than half of radiation dose reduction in females and overweight patients than conventional single-bolus computed tomography urography. Transl Oncol 14(8):101151. https://doi.org/10.1016/j.tranon.2021.101151
Taniguchi LS, Torres US, Souza SM, Torres LR, D’Ippolito G (2017) Are the unenhanced and excretory CT phases necessary for the evaluation of acute pyelonephritis? Acta Radiol 58(5):634–640. https://doi.org/10.1177/0284185116665424. (Epub 2016 Sep 30 PMID: 27563103)
Kataria B, Nilsson Althén J, Smedby Ö, Persson A, Sökjer H, Sandborg M (2019) Image quality and pathology assessment in CT Urography: when is the low-dose series sufficient? BMC Med Imaging 19(1):64. https://doi.org/10.1186/s12880-019-0363-z. (PMID:31399078;PMCID:PMC6688276)
Hack K, Pinto PA, Gollub MJ (2012) Targeted delayed scanning at CT urography: a worthwhile use of radiation? Radiology 265(1):143–150. https://doi.org/10.1148/radiol.12110548. (Epub 2012 Aug 1 PMID: 22855323)
Rud E, Galtung KF, Lauritzen PM, Baco E, Flatabø T, Sandbæk G (2020) Examining the upper urinary tract in patients with hematuria-time to revise the CT urography protocol? Eur Radiol 30(3):1664–1670. https://doi.org/10.1007/s00330-019-06521-0. (Epub 2019 Nov 20 PMID: 31748856)
Dickerson EC, Dillman JR, Smith EA, DiPietro MA, Lebowitz RL, Darge K (2015) Pediatric MR urography: indications, techniques, and approach to review. Radiographics 35(4):1208–1230. https://doi.org/10.1148/rg.2015140223. (PMID: 26172361)
Takahashi N, Kawashima A, Glockner JF, Hartman RP, Kim B, King BF (2009) MR urography for suspected upper tract urothelial carcinoma. Eur Radiol 19(4):912–923. https://doi.org/10.1007/s00330-008-1228-y. (Epub 2008 Nov 27 PMID: 19037644)
Chung AD, Schieda N, Shanbhogue AK, Dilauro M, Rosenkrantz AB, Siegelman ES (2016) MRI evaluation of the urothelial tract: pitfalls and solutions. AJR Am J Roentgenol 207(6):W108–W116. https://doi.org/10.2214/AJR.16.16348. (Epub 2016 Sep 9 PMID: 27611739)
Tan WS, Sarpong R, Khetrapal P, Rodney S, Mostafid H, Cresswell J, Hicks J, Rane A, Henderson A, Watson D, Cherian J, Williams N, Brew-Graves C, Feber A, Kelly JD; DETECT I Trial Collaborators (2018) Can renal and bladder ultrasound replace computerized tomography urogram in patients investigated for microscopic hematuria? J Urol. 200(5):973–980. https://doi.org/10.1016/j.juro.2018.04.065. (Epub 2018 Apr 24. PMID: 29702097; PMCID: PMC6179963)
D’Angelo T, Cicero G, Mazziotti S, Ascenti G, Albrecht MH, Martin SS, Othman AE, Vogl TJ, Wichmann JL (2019) Dual energy computed tomography virtual monoenergetic imaging: technique and clinical applications. Br J Radiol 92(1098):20180546. https://doi.org/10.1259/bjr.20180546. (Epub 2019 Apr 9. PMID: 30919651; PMCID: PMC6592074)
Cicero G, Ascenti G, Albrecht MH, Blandino A, Cavallaro M, D’Angelo T, Carerj ML, Vogl TJ, Mazziotti S (2020) Extra-abdominal dual-energy CT applications: a comprehensive overview. Radiol Med 125(4):384–397. https://doi.org/10.1007/s11547-019-01126-5. (Epub 2020 Jan 10 PMID: 31925704)
Zopfs D, Laukamp KR, Pinto Dos Santos D, Sokolowski M, GroßeHokamp N, Maintz D, Borggrefe J, Persigehl T, Lennartz S (2019) Low-keV virtual monoenergetic imaging reconstructions of excretory phase spectral dual-energy CT in patients with urothelial carcinoma: a feasibility study. Eur J Radiol 116:135–143. https://doi.org/10.1016/j.ejrad.2019.05.003. (Epub 2019 May 6. PMID: 31153554)
Manoharan D, Sharma S, Das CJ, Kumar R, Kumar P (2020) Split bolus dual-energy CT urography after urine dilution: a one-stop shop for detection and characterisation of urolithiasis. Clin Radiol 75(8):643.e11-643.e18. https://doi.org/10.1016/j.crad.2020.03.020. (Epub 2020 Apr 25 PMID: 32345438)
Shuman WP, Mileto A, Busey JM, Desai N, Koprowicz KM (2019) Dual-energy CT urography With 50% reduced iodine dose versus single-energy CT urography with standard iodine dose. AJR Am J Roentgenol 212(1):117–123. https://doi.org/10.2214/AJR.18.19720. (Epub 2018 Nov 13 PMID: 30422713)
Kaza RK, Ananthakrishnan L, Kambadakone A, Platt JF (2017) Update of dual-energy CT applications in the genitourinary tract. AJR Am J Roentgenol 208(6):1185–1192. https://doi.org/10.2214/AJR.16.17742. (Epub 2017 Mar 16 PMID: 28301210)
Ascenti G, Mileto A, Gaeta M, Blandino A, Mazziotti S, Scribano E (2013) Single-phase dual-energy CT urography in the evaluation of haematuria. Clin Radiol 68(2):e87-94. https://doi.org/10.1016/j.crad.2012.11.001. (Epub 2012 Dec 6 PMID: 23219453)
Mangold S, Thomas C, Fenchel M, Vuust M, Krauss B, Ketelsen D, Tsiflikas I, Claussen CD, Heuschmid M (2012) Virtual nonenhanced dual-energy CT urography with tin-filter technology: determinants of detection of urinary calculi in the renal collecting system. Radiology 264(1):119–125. https://doi.org/10.1148/radiol.12110851. (Epub 2012 May 8 PMID: 22570506)
Moon JW, Park BK, Kim CK, Park SY (2012) Evaluation of virtual unenhanced CT obtained from dual-energy CT urography for detecting urinary stones. Br J Radiol 85(1014):e176–e181. https://doi.org/10.1259/bjr/19566194. (Epub 2011 Sep 6. PMID: 21896665; PMCID: PMC3474096)
Sahni VA, Shinagare AB, Silverman SG (2013) Virtual unenhanced CT images acquired from dual-energy CT urography: accuracy of attenuation values and variation with contrast material phase. Clin Radiol 68(3):264–271. https://doi.org/10.1016/j.crad.2012.08.004. (Epub 2012 Sep 10 PMID: 22974566)
McCoombe K, Dobeli K, Meikle S, Llewellyn S, Kench P (2022) Sensitivity of virtual non-contrast dual-energy CT urogram for detection of urinary calculi: a systematic review and meta-analysis. Eur Radiol. https://doi.org/10.1007/s00330-022-08939-5
Xiao JM, Hippe DS, Zecevic M, Zamora DA, Cai LM, Toia GV, Chandler AG, Dighe MK, O’Malley RB, Shuman WP, Wang CL, Mileto A (2021) Virtual unenhanced dual-energy CT images obtained with a multimaterial decomposition algorithm: diagnostic value for renal mass and urinary stone evaluation. Radiology 298(3):611–619. https://doi.org/10.1148/radiol.2021192448. (Epub 2021 Jan 19 PMID: 33464180)
Funding
The authors declare that they did not receive any funding for this work and they have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors have not disclosed any competing interests.
Ethical approval
This work was in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Ascenti, G., Cicero, G., Cardone, G. et al. Cornerstones of CT urography: a shared document by the Italian board of urogenital radiology. Radiol med 128, 601–611 (2023). https://doi.org/10.1007/s11547-023-01623-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11547-023-01623-8