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Simulation Studies of Photoacoustic Response from Gold-Silica Core-Shell Nanoparticles

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Abstract

Metal nanoparticles especially of noble metals are used as an exogenous contrast agent for biomedical photoacoustic (PA) imaging in the tissue transmission window extending from visible to near infrared 700–1100 nm band. Different geometrical configurations of gold and silver nanoparticles like spherical core-shell, nanorod, and nanocages are promising candidates for thermoplasmonics, photothermal therapy, photothermal imaging, and photoacoustic imaging. In the current study, we simulated the photoacoustic response of gold and silica core-shell nanoparticle in water medium. Finite element simulations were carried out to study the spectral absorption response and effect of nanosecond laser pulse excitation on the spatial/temporal temperature as well as photoacoustic pressure variations of different core-shell geometry of nanoparticle. We have optimized the dimensions of gold nanosphere, gold-silica, and silica-gold core-shell geometries for optimum photoacoustic conversion efficiency. Further, the effect of shell thickness on the pulse photoacoustic signals for core-shell gold-silica and silica-gold nanoparticle has been studied. We concluded that silica-gold core-shell nanoparticles possess better photoacoustic conversion efficiency in comparison to gold nanosphere and gold-silica core-shell geometries. The prime aim of this study is to design efficient nano-probes for photoacoustic imaging, photoacoustic tomography, photothermal therapy, and drug delivery.

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Authors and Affiliations

  1. Laser Science and Technology Centre, DRDO, Delhi, 110054, India

    Deepak Kumar & Devinder Pal Ghai

  2. Department of Physics, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India

    Deepak Kumar & R. K. Soni

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  1. Deepak Kumar
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  2. Devinder Pal Ghai
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  3. R. K. Soni
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Correspondence to Deepak Kumar.

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Kumar, D., Ghai, D.P. & Soni, R.K. Simulation Studies of Photoacoustic Response from Gold-Silica Core-Shell Nanoparticles. Plasmonics 13, 1833–1841 (2018). https://doi.org/10.1007/s11468-018-0697-3

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  • DOI: https://doi.org/10.1007/s11468-018-0697-3

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