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Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

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  • SPECIAL TOPIC: Gut microbiome and metabolism
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Abstract

Bile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune homeostasis. Through the enterohepatic circulation, BAs are synthesized, metabolized, and reabsorbed, with a portion entering the vascular circulation and distributing systemically. This allows BAs to interact with receptors in all major organs, leading to organ-organ interactions that regulate both local and global metabolic processes, as well as the immune system. This review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation, including in the brain, heart, liver, intestine, eyes, skin, adipose tissue, and muscle. Targeting BA synthesis and receptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (82122012, 82270917) and Shanghai Research Center for Endocrine and Metabolic Diseases (2022ZZ01002).

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  1. School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China

    Wei Jia, Yitao Li & Kenneth C. P. Cheung

  2. Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China

    Xiaojiao Zheng

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Jia, W., Li, Y., Cheung, K.C.P. et al. Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis. Sci. China Life Sci. (2023). https://doi.org/10.1007/s11427-023-2353-0

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