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First way of enantioselective synthesis of moxifloxacin intermediate

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Abstract

A new method of enantioselective synthesis of (S,S)-2,8-diazobicyclo [4.3.0] nonane was found by using (R)-2-amino-2- phenyl-ethanol as chiral induction reagent. The entire synthetic process included 8 steps which were easy to operate with high yield. The purification method was only simple recrystallization or even used directly in the next step without further purification. The total yield was 29%.

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Correspondence to Zhuo Tang or XiaoMei Zhang.

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Li, G., Wu, L., Fu, Q. et al. First way of enantioselective synthesis of moxifloxacin intermediate. Sci. China Chem. 56, 307–311 (2013). https://doi.org/10.1007/s11426-012-4803-7

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  • DOI: https://doi.org/10.1007/s11426-012-4803-7

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