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Investigation of the pharmacokinetics and determination of certain cephalosporins in rabbit plasma by a kinetic spectrophotometric method with the aid of chemometrics

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Abstract

This paper describes a kinetic spectrophotometric method for simultaneous determination of three cephalosporin antibiotics, cephradine, cefaclor and cefixime, with the aid of chemometrics. The method relies on their oxidation with KMnO4 to produce green manganate with different kinetic rates in alkaline medium. The proposed method was successfully applied to a pharmacokinetic study of three cephalosporin antibiotics in rabbit plasma via intravenous injections. The results indicated that the amount of cephradine, cefaclor and cefixime were reduced rapidly in rabbit blood, showing clear dose-dependency and the half-life of cefixime (160 min) was longer than those of cephradine (60 min) and cefaclor (60 min).

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Authors and Affiliations

  1. State Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047, China

    YongNian Ni

  2. Department of Chemistry, Nanchang University, Nanchang, 330031, China

    YongNian Ni & JinFeng Chen

  3. Chemistry Faculty of Science and Technology, Queensland University of Technology, Brisbane, 4001, Australia

    Serge Kokot

Authors
  1. YongNian Ni
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  2. JinFeng Chen
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  3. Serge Kokot
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Correspondence to YongNian Ni.

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Ni, Y., Chen, J. & Kokot, S. Investigation of the pharmacokinetics and determination of certain cephalosporins in rabbit plasma by a kinetic spectrophotometric method with the aid of chemometrics. Sci. China Chem. 54, 827–834 (2011). https://doi.org/10.1007/s11426-010-4125-6

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  • DOI: https://doi.org/10.1007/s11426-010-4125-6

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