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Biocompatibility and in vitro antineoplastic drug-loaded trial of titania nanotubes prepared by anodic oxidation of a pure titanium

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Abstract

TiO2 nanotube (NT) arrays have been prepared by anodic oxidation of a Ti sheet, and carbon-deposited TiO2 NT arrays have been prepared by annealing TiO2 NT arrays in carbon atmosphere. The biocompatibility of the as-prepared NT arrays was investigated by observing the growth of osteosarcoma (MG-63) cells on the NT arrays. The application of the TiO2 NT arrays as a drug delivery vehicle was investigated. Both the TiO2 NTs and the carbon-modified TiO2 NTs have good biocompatibility supporting the normal growth and adhesion of MG-63 cells with no need of extracellular matrix protein coating. The one end-opened TiO2 NTs can be easily filled with drugs, working as an efficient drug delivery vehicle.

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Authors and Affiliations

  1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China

    XiLin Xiao, LiXia Yang, ManLi Guo, ChunFeng Pan, QingYun Cai & ShouZhuo Yao

  2. College of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, China

    XiLin Xiao

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  1. XiLin Xiao
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  2. LiXia Yang
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  3. ManLi Guo
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  4. ChunFeng Pan
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  5. QingYun Cai
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  6. ShouZhuo Yao
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Correspondence to QingYun Cai.

Additional information

Supported by the National Natural Science Foundation of China (Grant Nos. 20775024 & 20827006) and the Natural Science Foundation of Hunan Province (Grant No. 09JJ4007)

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Xiao, X., Yang, L., Guo, M. et al. Biocompatibility and in vitro antineoplastic drug-loaded trial of titania nanotubes prepared by anodic oxidation of a pure titanium. Sci. China Ser. B-Chem. 52, 2161–2165 (2009). https://doi.org/10.1007/s11426-009-0240-7

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  • DOI: https://doi.org/10.1007/s11426-009-0240-7

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