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Ellagic acid glycosides with hepatoprotective activity from traditional Tibetan medicine Potentilla anserina

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Abstract

Two new gallic acid glycosides, potentillanosides G (1) and H (2), were newly isolated from the methanol extract of the tuberous roots of Potentilla anserina (Rosaceae), together with a known compound, ellagic acid 3-O-α-l-rhamnopyranoside (3). Their structures were elucidated on the basis of chemical and physicochemical evidence. Among the constituents, potentillanoside H (2, IC50 = 99.5 μM) was found to show hepatoprotective activity.

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Fig. 1
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Acknowledgements

This work was supported by the MEXT-Supported Program for the Strategic Research Foundation at Private Universities, 2014–2018, Japan (S1411037, TM) as well as JSPS KAKENHI, Japan, Grant numbers 15K08008 (TM), 15K08009 (KN), and 16K08313 (OM). Financial support by the Kobayashi International Scholarship Foundation, Japan, is also acknowledged (TM).

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Authors and Affiliations

  1. Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan

    Toshio Morikawa, Katsuya Imura, Yoshinori Akagi, Osamu Muraoka & Kiyofumi Ninomiya

  2. Antiaging Center, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan

    Toshio Morikawa, Osamu Muraoka & Kiyofumi Ninomiya

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  1. Toshio Morikawa
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  2. Katsuya Imura
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  3. Yoshinori Akagi
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  4. Osamu Muraoka
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  5. Kiyofumi Ninomiya
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Correspondence to Toshio Morikawa.

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Morikawa, T., Imura, K., Akagi, Y. et al. Ellagic acid glycosides with hepatoprotective activity from traditional Tibetan medicine Potentilla anserina . J Nat Med 72, 317–325 (2018). https://doi.org/10.1007/s11418-017-1137-y

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