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Bioactive cyclolanstane-type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao

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Abstract

Twelve cyclolanstane-type saponins including six new ones, astrolanosaponins A1 (1), A2 (2), B (3), C (4), D (5), and E (6) were obtained from the stem of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, and their structures were elucidated by chemical and spectroscopic methods. Of the known ones, cycloastragenol-3-O-β-D-glucopyranoside (7), astraverrucin II (8), cycloaraloside E (9), huangqiyenin A (10), and huangqiyenin B (11) were isolated from the species first. Meanwhile, compounds 1–3, 5–9, and aleksandroside I (12) showed inhibitory effects on triglyceride accumulation in HepG2 cells.

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References

  1. Li X, Qu L, Dong Y, Han L, Liu E, Fang S, Zhang Y, Wang T (2014) A review of recent research progress on the astragalus genus. Molecules 19:18850–18880

    Article  PubMed  Google Scholar 

  2. Verotta L, Guerrini M, El-Sebakhy NA, Asaad AM, Toaima SM, Abou-Sheer ME, Luo YD, Pezzuto JM (2001) Cycloartane saponins from Astragalus peregrinus as modulators of lymphocyte proliferation. Fitoterapia 72:894–905

    Article  CAS  PubMed  Google Scholar 

  3. Pistelli L, Pardossi S, Flamini G, Bertoli A, Manunta A (1997) Three cycloastragenol glucosides from Astragalus verrucosus. Phytochemistry 45:585–587

    Article  CAS  Google Scholar 

  4. Isaev MI, Abubakirov NK (1990) Triterpene glycosides of Astragalus and their genins. XXXIV. Cycloaraloside E from Astragalus amarus. Khim Prir Soedin 26:559–561

    Google Scholar 

  5. Ma Y, Tian Z, Kuang H, Yuan C, Shao C, Ohtani K, Kasai R, Tanaka O, Okada Y, Okuyama T (1997) Studies of the constituents of Astragalus membranaceus Bunge. III. Structures of triterpenoidal glycosides, huangqiyenins A and B, from the leaves. Chem Pharm Bull 45:358–361

    Article  CAS  Google Scholar 

  6. Naubeev TKH, Uteniyazov KK, Kachala VV, Shashkov AS (2007) Cyclochivinoside B from the aerial part of Astragalus chivensis. Chem Nat Comp 43:166–169

    Article  CAS  Google Scholar 

  7. Zhang Y, Wu C, Guo L, Chen Y, Han L, Liu E, Gao X, Wang T (2013) Triglyceride accumulation inhibitory effects of phenylpropanoid glycosides from Boschniakia rossica Fedtsch et Flerov. Fitoterapia 85:69–75

    Article  CAS  PubMed  Google Scholar 

  8. Gülcemal D, Masullo M, Bedir E, Festa M, Karayıldırım T, Alankus-Caliskan O, Piacente S (2012) Triterpene glycosides from Astragalus angustifolius. Planta Med 78:720–729

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This project was supported by the Program for New Century Excellent Talents in University (NCET-12-1069), the Program for Tianjin Innovative Research Team in University (TD12-5033), and the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT IRT_14R41).

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Authors and Affiliations

  1. Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin, 300193, China

    Tingting Wang, Lifeng Han, Yi Zhang & Tao Wang

  2. Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin, 300193, China

    Jingya Ruan, Xiaoxia Li, Liping Chao, Pingping Shi, Lifeng Han, Yi Zhang & Tao Wang

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  1. Tingting Wang
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  2. Jingya Ruan
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  3. Xiaoxia Li
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  4. Liping Chao
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  5. Pingping Shi
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  7. Yi Zhang
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  8. Tao Wang
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Correspondence to Yi Zhang or Tao Wang.

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Wang, T., Ruan, J., Li, X. et al. Bioactive cyclolanstane-type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao. J Nat Med 70, 198–206 (2016). https://doi.org/10.1007/s11418-015-0959-8

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  • DOI: https://doi.org/10.1007/s11418-015-0959-8

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