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Zöliakie

Epidemiologie, Pathogenese, Differenzialdiagnostik und Therapie

Celiac disease

Epidemiology, pathogenesis, differential diagnosis, and treatment

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Zusammenfassung

Bei der Zöliakie wird bei Prädisponierten im Rahmen einer immunologischen Reaktion des intestinalen Immunsystems auf den Getreidebestandteil Gluten die Architektur der Dünndarmmukosa so verändert, dass eine Malabsorption entsteht. Gesteigertes Interesse für dieses Krankheitsbild kam mit den kürzlich in verschiedenen großen Studien ermittelten, unerwartet hohen Zöliakie-Prävalenzwerten von ca. 1% auf. Die Forschung der letzten Jahre auf dem Gebiet der Immunpathogenese der Zöliakie hat zudem wichtige Anteile der genetischen und immunologischen Ursachen dieser Erkrankung aufgedeckt. Dies trug dazu bei, dass die Zöliakie inzwischen eine immungenetische Modellerkrankung ist. Neue wie bereits seit längerem etablierte Erkenntnisse zur Epidemiologie, Pathogenese, Diagnostik und Therapie werden im folgenden Beitrag diskutiert.

Abstract

In celiac disease (CD) an immune response of the intestinal immune system to the grain component gluten causes damage to the mucosa of the small intestine and subsequently malabsorption in predisposed patients. Increased interest in CD was awakened due to the results of recently published large studies where unexpectedly high prevalence values of 1% for this disease were reported. Recent research in the field of the immunopathology of CD has revealed important genetic and immunological causes making CD an immunogenetic model disease. Recent insights and established facts of CD epidemiology, pathogenesis, diagnostics, and treatment are discussed in this article.

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Interessenkonflikt

Der korrespondierende Autor weist auf folgende Beziehung hin: Vortragshonorar von Falk.

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Authors and Affiliations

  1. Klinik für Gastroenterologie, Rheumatologie und Infektiologie, Charité, Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Deutschland

    M. Schumann, S. Daum, J.-D. Schulzke & M. Zeitz

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  1. M. Schumann
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  2. S. Daum
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  3. J.-D. Schulzke
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  4. M. Zeitz
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Correspondence to M. Schumann.

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Schumann, M., Daum, S., Schulzke, JD. et al. Zöliakie. Gastroenterologe 4, 19–26 (2009). https://doi.org/10.1007/s11377-008-0238-2

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  • DOI: https://doi.org/10.1007/s11377-008-0238-2

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