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Sirtuins, aging, and cardiovascular risks

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Abstract

The sirtuins comprise a highly conserved family proteins present in virtually all species from bacteria to mammals. Sirtuins are members of the highly conserved class III histone deacetylases, and seven sirtuin genes (sirtuins 1–7) have been identified and characterized in mammals. Sirtuin activity is linked to metabolic control, apoptosis, cell survival, development, inflammation, and healthy aging. In this review, we summarize and discuss the potential mutual relations between each sirtuin and cardiovascular health and the impact of sirtuins on oxidative stress and so age-related cardiovascular disorders, underlining the possibility that sirtuins will be novel targets to contrast cardiovascular risks induced by aging.

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Article 01 November 2022

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Sincere thanks to Miss Stefania Castrezzati and Mrs. Lorena Giugno.

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  1. Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123, Brescia, Italy

    Gaia Favero, Lorenzo Franceschetti, Luigi Fabrizio Rodella & Rita Rezzani

  2. Interdipartimental University Center of Research “Adaption and Regeneration of Tissues and Organs (ARTO)”, Brescia, Italy

    Luigi Fabrizio Rodella & Rita Rezzani

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  1. Gaia Favero
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Favero, G., Franceschetti, L., Rodella, L.F. et al. Sirtuins, aging, and cardiovascular risks. AGE 37, 65 (2015). https://doi.org/10.1007/s11357-015-9804-y

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