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The role of N6-methyladenosine methylation in PAHs-induced cancers

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Abstract

Polycyclic aromatic hydrocarbons (PAHs), which are a wide range of environmental toxicants, may act on humans through inhalation, ingestion, and skin contact, resulting in a range of toxic reactions. Epidemiological studies showed that long-term exposure to PAHs in the occupational and living environment results in a substantial rise in the incidence rate of many cancers in the population, so the prevention and treatment of these diseases have become a major worldwide public health problem. N6-methyladenosine (m6A) modification greatly affects the metabolism of RNA and is implicated in the etiopathogenesis of many kinds of diseases. In addition, m6A-binding proteins have an important role in disease development. The abnormal expression of these can cause the malignant proliferation, migration, invasion, and metastasis of cancers. Furthermore, a growing number of studies revealed that environmental toxicants are one of the cancer risk factors and are related to m6A modifications. Exposure to environmental toxicants can alter the methylation level of m6A and the expression of the m6A-binding protein, thus promoting the occurrence and development of cancers through diverse mechanisms. m6A may serve as a biomarker for early environmental exposure. Through the study of m6A, we can find the health injury early, thus providing a new sight for preventing and curing environmental health-related diseases.

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Funding

This work was supported by the National Natural Science Foundation of China [grant numbers 82002998 and 81872597]; the Medical Science and Technology Research Project in Henan Province [grant number LHGJ20190042]; the Youth Talent Support Project of Henan Province [grant number 2021HYTP045]; the Programs for the Collaborative Innovation Major Project of Zhengzhou [grant number 20XTZX08017]; the Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University [grant number ZYCXTD2023005] and the Henan Medical Science and Technology Research Program Joint Construction Project [grant number 2018020196].

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  1. Yujie Wei and Xiaona Guo are equal contributors.

Authors and Affiliations

  1. National Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1 Jianshe Road, Erqi District, Zhengzhou, 450052, Henan, China

    Yujie Wei, Lifeng Li, Longhao Wang, Chengxin Chen, Shilong Sun, Yaqi Yang, Jie Zhao & Xiaoran Duan

  2. Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

    Yujie Wei, Wenhua Xue, Chengxin Chen, Shilong Sun, Jie Zhao & Xiaoran Duan

  3. Medical School, Huanghe Science and Technology University, Zhengzhou, Henan, China

    Xiaona Guo & Xiaoran Duan

  4. Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China

    Wu Yao & Wei Wang

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  1. Yujie Wei
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Contributions

All authors contributed to the idea and writing of the entire manuscript. YW and XG: project administration, writing—original draft, conceptualization, and methodology. LL and WX: supervision, conceptualization, methodology, investigation, and data curation. LW, CC, SS, YY, and YW: investigation, resources, visualization, and writing—review and editing. WW, JZ, and XD: project administration and funding acquisition.

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Correspondence to Xiaoran Duan.

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Wei, Y., Guo, X., Li, L. et al. The role of N6-methyladenosine methylation in PAHs-induced cancers. Environ Sci Pollut Res 30, 118078–118101 (2023). https://doi.org/10.1007/s11356-023-30710-6

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