Skip to main content
SpringerLink
Log in

Association between urinary IPM3 and the presence of cardio-cerebrovascular diseases: a cross-sectional study

  • Research Article
  • Published:
Environmental Science and Pollution Research Aims and scope Submit manuscript

Abstract

Our study aims to investigate the association of urinary IPM3 and cardio-cerebrovascular diseases (CVD) in general adults. A total of 1775 participants were enrolled from the National Health and Nutrition Examination Surveys. Urinary levels of IPM3 were measured by LC/MS as exposure to isoprene. The associations between isoprene exposure and the risk of CVD were evaluated by restricted cubic splines based on multivariable logistic regression models. The prevalence of CVD was significantly higher across IPM3 quartiles. Comparing with the lowest quartile, the highest quartile was associated with 2.47-fold risk of CVD (odds ratio: 2.47, 95% confidence interval: 1.40–4.39, P = 0.002). Restricted cubic spline confirmed that the levels of urinary IPM3 were linearly associated with cardio-cerebrovascular diseases, angina and heart attack, while nonlinearly related to CHF and CAD. In conclusion, the urinary IPM3, as a long-term isoprene exposure, was associated with the presence of cardio-cerebrovascular diseases, including CHF, CAD, angina, and heart attack.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Data availability

Data described in the manuscript will be available upon request from the corresponding author.

References

  • Alkhouri N, Singh T, Alsabbagh E, Guirguis J, Chami T, Hanouneh I, Grove D, Lopez R, Dweik R (2015) Isoprene in the exhaled breath is a novel biomarker for advanced fibrosis in patients with chronic liver disease: a pilot study. Clin Transl Gastroenterol 6:e112

    Article  CAS  Google Scholar 

  • Alwis KU, Blount BC, Britt AS, Patel D, Ashley DL (2012) Simultaneous analysis of 28 urinary VOC metabolites using ultra high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS). Anal Chim Acta 750:152–160

    Article  CAS  Google Scholar 

  • Alwis KU, Bailey TL, Patel D, Wang L, Blount BC (2016) Measuring urinary N-acetyl-S-(4-hydroxy-2-methyl-2-buten-1-yl)-L-cysteine (IPMA3) as a potential biomarker of isoprene exposure. Anal Chim Acta 941:61–66

    Article  CAS  Google Scholar 

  • Eaves LA, Smeester L, Hartwell HJ, Lin YH, Arashiro M, Zhang Z, Gold A, Surratt JD, Fry RC (2020) Isoprene-derived secondary organic aerosol induces the expression of microRNAs associated with inflammatory/oxidative stress response in lung cells. Chem Res Toxicol 33:381–387

    Article  CAS  Google Scholar 

  • Fuchs D, Jamnig H, Heininger P, Klieber M, Schroecksnadel S, Fiegl M, Hackl M, Denz H, Amann A (2012) Decline of exhaled isoprene in lung cancer patients correlates with immune activation. J Breath Res 6:027101

    Article  CAS  Google Scholar 

  • Mochalski P, Diem E, Unterkofler K, Mundlein A, Drexel H, Mayhew CA, Leiherer A (2019) In vitro profiling of volatile organic compounds released by Simpson-Golabi-Behmel syndrome adipocytes. J Chromatogr B Analyt Technol Biomed Life Sci 1104:256–261

    Article  CAS  Google Scholar 

  • Nieuwenhuijsen MJ (2018) Influence of urban and transport planning and the city environment on cardiovascular disease. Nat Rev Cardiol 15:432–438

    Article  Google Scholar 

  • Srivastva N, Singh A, Bhardwaj Y, Dubey SK (2018) Biotechnological potential for degradation of isoprene: a review. Crit Rev Biotechnol 38:587–599

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Geriatric Hospital of Nanjing Medical University, Jiangsu Province Official Hospital, Nanjing, China

    Qi Tian & Danqing Huang

Authors
  1. Qi Tian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Danqing Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

DQ H designed the study; Q T performed the statistical analysis. All authors approved the publication.

Corresponding author

Correspondence to Danqing Huang.

Ethics declarations

Ethics approval and consent to participate

The protocol was approved by the Institutional Review Board of National Center for Health Statistics and no new data was added.

Consent for publication

Not applicable.

Conflict of interest

The authors declare no competing interests.

Additional information

Responsible Editor: Lotfi Aleya

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tian, Q., Huang, D. Association between urinary IPM3 and the presence of cardio-cerebrovascular diseases: a cross-sectional study. Environ Sci Pollut Res 30, 75817–75822 (2023). https://doi.org/10.1007/s11356-023-27324-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11356-023-27324-3

Keywords

Search

Navigation