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Nanosilver-functionalized polysaccharides as a platform for wound dressing

  • Review Article
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Abstract

Polysaccharides that are naturally sourced have enormous promise as wound dressings, due to their wider availability and reasonable cost and good biocompatibility. Furthermore, nanosilver extensively applied in wound treatment is attributed to its broad spectrum of antimicrobial effects and lesser drug resistance. Consequently, wound dressings in corporating nanosilver have attracted wide-scale interest in wound healing, and nanosilver-functionalized polysaccharide-based wound dressings present an affordable option for healing of chronic wounds. This review encompasses preparation methods, classification, and antibacterial performances of nanosilver wound dressings. The prospective research arenas of nanosilver-based wound polysaccharide dressings are also elaborated. The review attempts to include a summary of the most recent advancements in silver nanotechnology as well as guidance for the investigation of nanosilver-functionalized polysaccharide-based wound dressings.

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Abbreviations

WHS:

Wound Healing Society

Hh:

Hedgehog

CS:

Chitosan

FDA:

Food and Drug Administration

MW:

Molecular weight

CDs:

Cyclodextrins

GAG:

Glycosaminoglycan

HSV:

Herpes simplex virus

NPs:

Nanoparticles

Ag-NPs:

Silver nanoparticles

MMP:

Matrix metalloproteinase

PS-AgNPs:

Polysaccharides silver nanoparticles

NHEK:

Natural human epidermal keratinocytes

SSD:

Silver sulfadiazine

PEH:

Polyelectrolyte hydrogels

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Acknowledgements

The authors extend their appreciation to the Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia for funding this research work through the project number ISP22-10.

Funding

This research was funded by Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia through the project number ISP22-10.

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Author notes

  1. Syam Mohan, Pranay Wal, Kamla Pathak, and Tapan Behl have equal contributions.

Authors and Affiliations

  1. School of Health Sciences, University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India

    Syam Mohan & Tapan Behl

  2. Substance Abuse and Toxicology Research Centre, Jazan University, Jazan, Saudi Arabia

    Syam Mohan, Hassan A. Alhazmi & Asaad Khalid

  3. Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, India

    Syam Mohan

  4. Pharmacy, Pranveer Singh Institute of Technology, National Highway-2, Bhauti Road, Kanpur, India

    Pranay Wal

  5. Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Etawah, India

    Kamla Pathak

  6. Royal College of Pharmacy & Health Sciences, Berhampur, Odisha, India

    Madhusmruti Khandai

  7. Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan, Saudi Arabia

    Hassan A. Alhazmi & Gulrana Khuwaja

  8. Medicinal and Aromatic Plants and Traditional Medicine Research Institute, National Center for Research, P. O. Box 2404, Khartoum, Sudan

    Asaad Khalid

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Contributions

PW, KP, SM, and TB: Conceived the study and wrote the first draft of the paper; MK, SM and HAA: Data compilation; GK and AK: Editing; TB and SM: Proof Read.

Corresponding author

Correspondence to Tapan Behl.

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Mohan, S., Wal, P., Pathak, K. et al. Nanosilver-functionalized polysaccharides as a platform for wound dressing. Environ Sci Pollut Res 30, 54385–54406 (2023). https://doi.org/10.1007/s11356-023-26450-2

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