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Correlation between the positive rate of SAA in children with respiratory tract infection and ambient temperature

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Abstract

The purpose of this study was to explore the application of serum amyloid A (SAA) in the outcome of upper respiratory tract infection in children by analyzing the correlation between the change of mean air temperature and the positive rate of SAA detection in children. Daily data on upper respiratory tract infection diseases and weather conditions were collected in 2016–2019. A quasi-Poisson regression with a distributed lag non-linear model was used to examine the association between temperature and SAA-positive rate. The positive rate of SAA had a moderate correlation with the temperature and a weak correlation with relative humidity. Low ambient temperature (7 °C, P1) was related to the increase in the positive rate of SAA, with the effect lag for 0–7 days (RR 1.34 (1.19~1.74)). The increase in the SAA-positive case induced by 27 °C (P75) could last for 0–14 days (RR 1.07 (1.01–1.08)), and high temperature (30 °C, P99) could reduce the positive rate of SAA. Our findings add additional evidence to the adverse effects of sub-optimal ambient temperature and provide useful information for public health programs targeting pediatric patients.

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Funding

This study was funded by the National Natural Science Fund of China (81871716, 81801474), the Science and Technology project Fund of Guangzhou (201704020109, 201707010019), the Natural Science Fund of Guangdong Province (2018A0303130314), and the Science and Technology Fund of Shenzhen (JCYJ20180306172502097), the fund from Guangzhou Institute of Pediatrics/Guangzhou Women and Children’s Medical Center (NO:IP-2019-009), and the fund from Guangzhou Women and Children’s Medical Center (No. CWCMC2020-6-017).

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Authors and Affiliations

  1. Department of Clinical Laboratory, Guangzhou Women and Children’s Medical Centre of Guangzhou Medical University, No. 9, Jinsui Road, Guangzhou, 510623, Guangdong, China

    Shanshui Zeng, Mengru Han, Fei Liu, Yan Long, Ming Jiang & Hongling Yang

Authors
  1. Shanshui Zeng
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  2. Mengru Han
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  3. Fei Liu
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  4. Yan Long
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  5. Ming Jiang
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  6. Hongling Yang
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Contributions

Hongling Yang conceived and directed the study; Shanshui Zeng and Mengru Han did the analysis and visualization; Shanshui Zeng, Mengru Han, Fei Liu, Min Jiang, and Yan Long collected the samples; Shanshui Zeng and Mengru Han drafted the manuscript; and Hongling Yang revised the manuscript.

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Correspondence to Hongling Yang.

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The authors declare no competing interests.

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Responsible Editor: Lotfi Aleya

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Zeng, S., Han, M., Liu, F. et al. Correlation between the positive rate of SAA in children with respiratory tract infection and ambient temperature. Environ Sci Pollut Res 28, 61072–61079 (2021). https://doi.org/10.1007/s11356-021-15033-8

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  • DOI: https://doi.org/10.1007/s11356-021-15033-8

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