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Association between sleep-disordered breathing and lower extremity artery disease: a meta-analysis

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Objective

Previous studies suggest a relationship between sleep disordered breathing (SDB) and lower extremity artery disease (LEAD) though disagreements remain. This study was performed to assess the association between SDB and LEAD in a metaanalysis.

Methods

PubMed and Embase databases were searched for observational studies. A random-effects model incorporating between-study heterogeneity was used to pool the data.

Results

The search revealed 7 studies including 152,885 participants. Patients with SDB had higher odds of LEAD (risk ratio [RR] = 1.32, 95% confidence interval [CI] = 1.07 to 1.63, p = 0.01, I 2 = 66%) compared to non-SDB participants. In subgroup analyses, SDB was related to higher odds of LEAD in patients with stroke or diabetes (RR = 3.28, p < 0.001) than in a community-derived population (RR = 1.17, p = 0.08; p for subgroup difference < 0.001). Furthermore, the odds of LEAD was increased in patients with moderate (RR = 1.34, 95% CI = 1.04 to 1.73, p = 0.02) or severe SDB (RR = 1.81, 95% CI = 1.08 to 3.03, p = 0.02), but not in those with mild SDB (RR = 0.94, 95% CI = 0.69 to 1.29, p = 0.71). Differences in study design or methods for LEAD diagnosis did not appear to affect the association between SDB and LEAD.

Conclusions

Patients with SDB have higher odds of LEAD compared to non-SDB participants.

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Authors and Affiliations

  1. Department of Vascular Surgery, Liuzhou People’s Hospital, Liuzhou, 545006, China

    Yuhong Chen, Xiaocheng Li & Liming Zhao

  2. Department of Neurosurgery, Liuzhou People’s Hospital, No. 8 Wenchang Road, Liuzhou, 545006, China

    Gang Wu

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  1. Yuhong Chen
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  4. Gang Wu
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Correspondence to Gang Wu.

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Chen, Y., Li, X., Zhao, L. et al. Association between sleep-disordered breathing and lower extremity artery disease: a meta-analysis. Sleep Breath 25, 227–236 (2021). https://doi.org/10.1007/s11325-020-02096-z

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  • DOI: https://doi.org/10.1007/s11325-020-02096-z

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