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Metabolic changes through hypoxia in humans and in yeast as a comparable cell model

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Abstract

Background

In several investigations on mountaineers under moderate hypoxia, at altitudes between 2,500 m and 4,500 m, weight loss occurs, fat levels in the serum and insulin resistance (in diabetic mountaineers) are reduced. Animal studies with different time dosage regimens of hypoxia in animal cages revealed different and partly confusing results regarding fat metabolism under hypoxia.

Hypotheses

Hypothesis for the change in glucose and fat metabolism include a HIF promoted higher leptin rate under hypoxia and an increased glucose transport in peripheral organs.

Discussion

This short review discusses some of the different investigations in this topic. In a second part it is shown how studies of metabolism in yeast cells with an upregulated glycolysis in the cell itself under hypoxic conditions could help to better understand metabolic changes under hypoxia.

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Conflict of interest statement

Both authors declare that they have no conflict of interest involved in this paper and no financial support by third parties to disclose.

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Authors and Affiliations

  1. Hermann Buhl Institute for Hypoxia and Sleep Medicine Research, Paracelsus Medical University, Salzburg, Austria

    Nikolaus C. Netzer

  2. Department of Internal Medicine, University Hospitals Ulm, Ulm, Germany

    Nikolaus C. Netzer

  3. Division of Cell Biology, Department of Biology and Natural Sciences, Paris Lodron University, Salzburg, Austria

    Michael Breitenbach

  4. Hermann Buhl Institute in the Fachklinik Ghersburg, Ghersburgstr. 9, 83043, Bad Aibling, Germany

    Nikolaus C. Netzer

Authors
  1. Nikolaus C. Netzer
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  2. Michael Breitenbach
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Correspondence to Nikolaus C. Netzer.

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Netzer, N.C., Breitenbach, M. Metabolic changes through hypoxia in humans and in yeast as a comparable cell model. Sleep Breath 14, 221–225 (2010). https://doi.org/10.1007/s11325-010-0342-7

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  • DOI: https://doi.org/10.1007/s11325-010-0342-7

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