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Interaction of purinergic receptors with GPCRs, ion channels, tyrosine kinase and steroid hormone receptors orchestrates cell function

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Abstract

Extracellular purines and pyrimidines have emerged as key regulators of a wide range of physiological and pathophysiological cellular processes acting through P1 and P2 cell surface receptors. Increasing evidence suggests that purinergic receptors can interact with and/or modulate the activity of other classes of receptors and ion channels. This review will focus on the interactions of purinergic receptors with other GPCRs, ion channels, receptor tyrosine kinases, and steroid hormone receptors. Also, the signal transduction pathways regulated by these complexes and their new functional properties are discussed.

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Acknowledgements

Support to this study by the National Research Council of Argentina (CONICET) and Universidad Nacional del Sur (Argentina) is gratefully acknowledged.

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  1. Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, B8000ICN, Bahía Blanca, Argentina

    Paola Scodelaro Bilbao, Sebastián Katz & Ricardo Boland

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  1. Paola Scodelaro Bilbao
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  2. Sebastián Katz
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  3. Ricardo Boland
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Correspondence to Paola Scodelaro Bilbao.

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Bilbao and Katz have equally contributed to this work

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Bilbao, P.S., Katz, S. & Boland, R. Interaction of purinergic receptors with GPCRs, ion channels, tyrosine kinase and steroid hormone receptors orchestrates cell function. Purinergic Signalling 8, 91–103 (2012). https://doi.org/10.1007/s11302-011-9260-9

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