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The diagnostic utility of size and apparent diffusion coefficient values for cervical lymph nodes in patients with osteomyelitis of the jaw bone

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Abstract

Purpose

The purpose of this study was to (1) clarify the size and apparent diffusion coefficient (ADC) value of lymph nodes (LN) in each state in their quantitative evaluation diffusion-weighted imaging, and (2) to determine the diagnostic utility of size and ADC values in the quantitative evaluation of LNs using diffusion-weighted imaging.

Methods

This was a retrospective cohort study at our hospital conducted between April 2017 and March 2019. A total of 50 patients (20 men, 30 women) with 118 LNs, aged 34–90 years (mean age 61.18 years), undergoing magnetic resonance imaging examination were included in the study. The predictor variable was disease status. The primary outcome variable was the mean size and ADC values of the LNs. The other variables were age and sex. Data were analyzed using a Kruskal–Wallis test, and

hoc Mann–Whitney tests with Bonferroni adjustment and a receiver operating characteristic (ROC) curve. P < 0.05 was considered to indicate statistical significance.

Results

We analyzed the records of 50 patients (118 LNs) with and without osteomyelitis. Of these, 21 had acute osteomyelitis, and 16 had chronic osteomyelitis. The size and ADC values of LNs in the osteomyelitis group were significantly greater and higher, respectively, than those in the non-myelitis group (P < 0.01). ROC analysis revealed a cutoff short-axis size of 4.42 and 4.04 mm for lymphadenopathy caused by osteomyelitis, corresponding to levels IB and level II, respectively. Moreover, the ADC cutoff values for the same were 0.85 and 0.86, respectively.

Conclusion

The results suggest that size and ADC values are useful parameters for the quantitative evaluation of lymphadenopathy caused by osteomyelitis.

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Abbreviations

ADC:

Apparent diffusion coefficient

LN:

Lymph nodes

ROC:

Receiver operating characteristic

CT:

Computed tomography

MRI:

Magnetic resonance imaging

US:

Ultrasonography

DWI:

Diffusion-weighted imaging

FOV:

Field of view

ROI:

Region of interest

ICC:

Intraclass correlation coefficient

AUC:

Area under the curve

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Acknowledgements

We would like to thank Editage (www.editage.com) for English language editing.

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Authors and Affiliations

  1. Department of Radiology, Nihon University School of Dentistry At Matsudo, 2-870-1 Sakaecho-Nishi, Matsudo, Chiba, 271-8587, Japan

    Hirotaka Muraoka, Kotaro Ito, Naohisa Hirahara, Tomohiro Komatsu, Takumi Kondo & Takashi Kaneda

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  1. Hirotaka Muraoka
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  2. Kotaro Ito
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  3. Naohisa Hirahara
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  4. Tomohiro Komatsu
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  5. Takumi Kondo
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  6. Takashi Kaneda
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Corresponding author

Correspondence to Hirotaka Muraoka.

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Ethics approval

We designed and conducted a retrospective cohort study, which was approved by Nihon University ethics committee (EC19-011).

Informed consent

The requirement to obtain written informed consent was waived for this retrospective study. All procedures followed the guidelines of the Declaration of Helsinki, Ethical Principles for Medical Research Involving Human Subjects.

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This article does not contain any studies with animal subjects performed by the any of the authors.

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Muraoka, H., Ito, K., Hirahara, N. et al. The diagnostic utility of size and apparent diffusion coefficient values for cervical lymph nodes in patients with osteomyelitis of the jaw bone. Oral Radiol 38, 192–198 (2022). https://doi.org/10.1007/s11282-021-00543-5

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  • DOI: https://doi.org/10.1007/s11282-021-00543-5

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