Abstract
Marine sediments are one of the largest habitats on Earth, and their unique ecology, such as high salinity, high pressure, and hypoxia, may activate certain silent genes in marine microbes, resulting in microbes, enzymes, active products, and specific metabolic pathways that can adapt to these specific ecological environments. Marine sediment-derived microorganisms and their bioactive metabolites are of great significance and have potential commercial development prospects for food, pharmaceutical, chemical industries, agriculture, environmental protection and human nutrition and health. In recent years, although there have been numerous scientific reports surrounding marine sediment-derived microorganisms and their bioactive metabolites, a comprehensive review of their research progress is lacking. This paper presents the development and renewal of traditional culture-dependent and omics analysis techniques and their application to the screening of marine sediment-derived microorganisms producing bioactive substances. It also highlights recent research advances in the last five years surrounding the types, functional properties and potential applications of bioactive metabolites produced by marine sediment-derived microorganisms. These bioactive metabolites mainly include antibiotics, enzymes, enzyme inhibitors, sugars, proteins, peptides, and some other small molecule metabolites. In addition, the review ends with concluding remarks on the challenges and future directions for marine sediment-derived microorganisms and their bioactive metabolites. The review report not only helps to deepen the understanding of marine sediment-derived microorganisms and their bioactive metabolites, but also provides some useful information for the exploitation and utilization of marine microbial resources and the mining of new compounds with potential functional properties.
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References
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This work was supported by the National Natural Science Foundation of China (32072205, 22138004), the first phase of the connotation construction of the 14th Five-Year Plan of Tibetan medicine (2021ZYYGH008).
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Hongli Yao collected research data and wrote original draft. Shuangping Liu conceive and co-ordinate the framework of the article. Tiantian Liu and Dongliang Ren made preliminary revisions to the paper. Qilin Yang and Zhilei Zhou organized and collected figures, tables, and references. Jian Mao provided the funding and made the final decision on the paper.
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Yao, H., Liu, S., Liu, T. et al. Screening of marine sediment-derived microorganisms and their bioactive metabolites: a review. World J Microbiol Biotechnol 39, 172 (2023). https://doi.org/10.1007/s11274-023-03621-4
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DOI: https://doi.org/10.1007/s11274-023-03621-4