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Serum endocan and circadian heart rate variability in non-dialysis stage 5 chronic kidney disease patients

  • Nephrology - Original Paper
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Abstract

Background

Chronic kidney disease (CKD) is very common now and is associated with high overall and cardiovascular mortality. Numerous studies have reported that elevated heart rate (HR) is a risk factor for cardiovascular mortality. We investigated the link between serum endocan and circadian heart rate variability in non-dialysis stage 5 CKD patients.

Methods

In a cross-sectional study, we enrolled 54 prevalent n non-dialysis stage 5 CKD patients (32 males, aged 48.2 ± 14.92 years). HR was measured with an automatic system. Serum endocan level was analyzed by ELISA.

Results

Night/day HR ratio was independently predicted by serum endocan level (P < 0.01) and hypertension history (P < 0.05). Adjusted R2 of the model was 0.222.

Conclusion

Increased serum endocan is significantly associated with circadian heart rate variability in non-dialysis stage 5 CKD patients. Further investigation is needed to explore the potential benefits of serum endocan lowering therapy in this patient group.

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Acknowledgements

The authors thank all the patients and staff of the Division of Nephrology.

Funding

This work was funded by grant from Chinese Society of Blood Purification Administration (CHABP2016-07), supported by Chinese Society of Nephrology Grant (13030310416), and funded by Special Supporting Program for Young Teachers in Kunming Medical University. BY was supported by a grant from Graduate Innovation Fund in Kunming Medical University.

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Authors and Affiliations

  1. Division of Nephrology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, China

    Yu Bao, Yi-An Wang, Hua Xiao, Ying Wang, Yan Wu, Yue Yan, Zhu Zhu, Mei Ni, Cheng-Xian Pi & Xing-Wei Zhe

  2. Division of Nephrology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China

    Ming-Yue Liu

  3. Division of Nephrology, Puer People’s Hospital, Pu’er, China

    Jun-Hua Yang

  4. Intensive Care Unit, General Hospital of Ningxia Medical University, Yinchuan, China

    Yan-Ting Li

  5. Division of Nephrology, Peking University Third Hospital, Beijing, China

    Xin-Kui Tian & Tao Wang

Authors
  1. Yu Bao
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  2. Yi-An Wang
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  3. Hua Xiao
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  4. Ying Wang
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  5. Yan Wu
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  6. Yue Yan
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  7. Zhu Zhu
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  8. Mei Ni
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  9. Cheng-Xian Pi
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  10. Ming-Yue Liu
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  11. Jun-Hua Yang
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  12. Yan-Ting Li
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  13. Xin-Kui Tian
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  14. Tao Wang
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  15. Xing-Wei Zhe
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Corresponding author

Correspondence to Xing-Wei Zhe.

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Conflict of interest

None of the authors declare any conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments of comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Cite this article

Bao, Y., Wang, YA., Xiao, H. et al. Serum endocan and circadian heart rate variability in non-dialysis stage 5 chronic kidney disease patients. Int Urol Nephrol 50, 2061–2066 (2018). https://doi.org/10.1007/s11255-018-1993-8

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  • DOI: https://doi.org/10.1007/s11255-018-1993-8

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