Abstract
In this study we evaluated the indications, complications, and the spectrum of histopathological results of percutaneous renal needle biopsy (PRNB) performed in our clinic. Between June 1990 and December 2006, 679 PRNBs were performed on native kidneys of 614 children (304 boys, 310 girls) with a mean age of 10.4 years. Most frequent indications for PRNB were nephrotic syndrome (47%), hematuria, and/or proteinuria (15.9%), acute renal failure (14.6%) and complex renal manifestations (18.9%). The overall complication rate was 15.2%. The most common complications were perirenal hematoma (12.4%) and macroscopic hematuria (2.6%). The most frequent histopathological group of diseases were glomerulopathies; these were diagnosed in 376 patients (61.2%) and included membranoproliferative glomerulonephritis (11.1%), mesangial proliferation (10.7%), diffuse proliferative glomerulonephritis (7.7%), and focal segmental glomerulosclerosis (7.3%) as the most frequent. The second most frequent group of histopathology was manifestations secondary to systemic diseases; these were shown in 195 patients (31.8%). Amyloidosis (11.4%) and Henoch–Schönlein nephritis (9.9%) made the majority of this group. In conclusion, our study demonstrated that PRNB is a safe procedure with usually transient complications showing the most frequent renal diseases that cause diagnostic and therapeutic difficulties for pediatric nephrologists.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Feneberg R, Schaefer F, Zieger B, Waldherr R, Mehls O, Scharer K (1998) Percutaneous renal biopsy in children: a 27-year experience. Nephron 79:438–446
Chesney DS, Brouhard BH, Cunningham RJ (1996) Safety and cost effectiveness of pediatric percutaneous renal biopsy. Pediatr Nephrol 10:493–495
Fogo AB (2004) Renal pathology. In: Avner ED, Harmon WE, Niaudet P (eds) Pediatric nephrology, 5th edn. Lippincott Williams & Wilkins, Philadelphia, pp 475–500
Edelmann CM, Churg J, Gerber MA, Travis LB (1992) Renal biopsy ındications: technique, and ınterpretation. In: Edelmann CM (ed) Pediatric kidney disease, 2nd edn. Little Brown and Company, Boston, pp 499–527
Rance CP (1990) When should renal biopsy be done? Clin Pediatr 29:653–664
Vassiliades VG, Bernardino ME (1991) Percutaneous renal and adrenal biopsies. Cardiovasc Intervent Radiol 14:50–54
Altebarmakian VK, Guthinger WP, Yakub YN, Gutierrez OH, Linke CA (1981) Percutaneous kidney biopsies. Urology XVIII:118–122
Carvajal HG, Travis LB, Srivastava RN, De Beukelaer MM, Dodge WF, Dupree E (1971) Percutaneous renal biopsy in children—an analysis of complications in 890 consecutive biopsies. Texas Rep Biol Med 29:253–264
Karafin L, Kendall AR, Fleisher DS (1970) Urologic complications in percutaneous renal biopsy in children. J Urol 103:332–335
Leiter E, Gribetz D, Cohen S (1972) Arteriovenous fistula after percutaneous needle biopsy—surgical repair with preservation of renal function. N Engl J Med 287:971–972
De Beukelaer MM, Schreiber MH, Dodge WF, Travis LB (1971) Intrarenal arteriovenous fistulas following needle biopsy of the kidney. J Pediatr 78:266–272
Sagar SJ, Kaye MB (1973) Systemic infection following needle biopsy of the kidney. J Urol 109:930
Ibarguen E, Sharp HL (1989) Gastrointestinal complications following percutaneous kidney biopsy. J Pediatr Surg 24:286–288
Fraser RA, Leary FJ (1973) Ureterocutaneous fistula following percutaneous renal biopsy. J Urol 109:931–933
Wijeyesinghe ECR, Richardson RMA, Uldall PR (1987) Temporary loss of renal function: an unusual complication of perinephric hemorrhage after percutaneous renal biopsy. Am J Kidney Dis 10:314–317
Kamitsuji H, Yoshioka K, Ito H, Japanese Society for Pediatric Nephrology (1999) Percutaneous renal biopsy in children: survey of pediatric nephrologists in Japan. Pediatr Nephrol 13:693–696
Hussain F, Watson AR, Hayes J, Evans J (2003) Standards for renal biopsies: comparison of inpatient and day care procedures. Pediatr Nephrol 18:53–56
White RHR, Poole C (1996) Day care renal biopsy. Pediatr Nephrol 10:408–411
Simckes AM, Blowey DL, Gyves KM, Alon US (2000) Success and safety of same-day kidney biopsy in children and adolescents. Pediatr Nephrol 14:946–952
Davis ID, Oehlenschlager W, O’Riordan MA, Avner ED (1998) Pediatric renal biopsy: should this procedure be performed in an outpatient setting? Pediatr Nephrol 12:96–100
Sumboonnanonda A, Srajai K, Vongjirad A, Suntornpoch V, Parichatikanond P (2002) Percutaneous renal biopsy in children. J Med Assoc Thai 85(Suppl. 2):S755–S761
Burstein DM, Schwartz MM, Kobert SM (1991) Percutaneous renal biopsy with the use of real-time ultrasound. Am J Nephrol 11:195–200
Carvalho E, Faria MdS, Nunes JPL, Sampaio S, Valbuena C (2006) Renal diseases: a 27-year renal biopsy study. J Nephrol 19:500–507
Mourani C, Hage G, Mallat S, Gerbaka B, Akatcherian C (1998) Renal biopsy in children in a developing country in 61 consecutive cases. J Med Liban 46:136–139
Li LS, Liu ZH (2004) Epidemiologic data of renal diseases from a single unit in China: analysis based on 13,519 renal biopsies. Kidney Int 66:920–923
Chen H, Tang Z, Zeng C, Hu W, Wang Q, Yu Y, Yao X, Wang J, Zhu M, Zhou H, Liu H, Liu Z, Li L (2003) Pathological demography of native patients in a nephrology center in China. Chin Med J 116:1377–1381
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Demircin, G., Delibaş, A., Bek, K. et al. A one-center experience with pediatric percutaneous renal biopsy and histopathology in Ankara, Turkey. Int Urol Nephrol 41, 933–939 (2009). https://doi.org/10.1007/s11255-008-9433-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11255-008-9433-9