Abstract
Purpose: The aim of this study was to assess the clinical efficacy of distigmine bromide, an anti-cholinesterase agent, deemed to improve detrusor function thereby restoring normal voiding patterns in patients suffering from detrusor underactivity. Materials and methods: A total of 27 patients (11 men and 16 women) with poor detrusor function were included in the study. The diagnosis was established using pressure-flow studies. All patients received distigmine bromide at a dose of 5 mg three times daily for 4 weeks and re-attended for a follow-up urodynamic investigation. The results of baseline pressure-flow studies were compared to those after completion of treatment. Results: Treatment with distigmine bromide resulted in a statistically significant reduction of residual volume and percent residual volume, obviating the need for intermittent self-catheterisation in 11 patients. In addition, maximum flow rate and detrusor pressure at maximum flow increased, although not significantly. The drug was generally well tolerated by the majority of patients. Conclusion: Distigmine bromide shows clinical efficacy in patients with poor detrusor function and may therefore be used alternatively in selected cases.
Similar content being viewed by others
References
P Abrams L Cardozo M Fall et al. (2002) ArticleTitleThe standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society Neurourol Urodyn 21 IssueID2 167–178 Occurrence Handle10.1002/nau.10052 Occurrence Handle11857671
J Lapides AC Diokno ST Silber BS Lowe (1972) ArticleTitleClean intermittent self catheterisation in the treatment of urinary tract disease J Urol 107 IssueID3 458–461 Occurrence Handle1:STN:280:CS2C38jktVw%3D Occurrence Handle5010715
AC Diokno LP Sonda JB Hollander J Lapides (1983) ArticleTitleFate of patients started on intermittent self-catheterisation therapy 10 years ago J Urol 129 IssueID6 1120–1122
FM Maynard AC Diokno (1982) ArticleTitleClean intermittent catheterisation for spinal cord injury patients J Urol 128 IssueID3 477–480 Occurrence Handle1:STN:280:BiyD3M%2FkvVA%3D Occurrence Handle7120549
FM Maynard AC Diokno (1984) ArticleTitleUrinary infections and complications during clean intermittent catheterisation following spinal cord surgery J Urol 132 IssueID5 943–946
I Perkash J Giroux (1993) ArticleTitleClean intermittent catheterisation in spinal cord injury patients: a follow-up study J Urol 149 IssueID5 1068–1071
Y Tanaka N Masumori N Itoh et al. (2001) ArticleTitleSymptomatic and urodynamic improvement by oral distigmine bromide in poor voiders after transurethral resection of the prostate Urology 57 IssueID2 270–274
NH Philp DG Thomas (1980) ArticleTitleThe effect of distigmine bromide on voiding in male paraplegic patients with reflex micturition Br J Urol 52 IssueID6 492–496
PH Smith JB Cook EWM Prasad (1974) ArticleTitleThe effect of distigmine bromide on bladder function after recent complete spinal cord injury Br J Urol 46 IssueID2 187–192
TB Vree J Waitzinger A Hammermaier S Radhofer-Welte (1999) ArticleTitleAbsolute bioavailability, pharmacokinetics, renal and biliary clearance of distigmine after a single oral dose in comparison to i.v. administration of 14C-distigmine bromide in healthy volunteers Int J Clin Pharmacol Ther 37 IssueID8 393–403
PJ Shah PH Abrams RG Choa et al. (1983) ArticleTitleDistigmine bromide and post-prostatectomy incontinence Br J Urol 55 IssueID2 229–232
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bougas, D.A., Mitsogiannis, I.C., Mitropoulos, D.N. et al. Clinical efficacy of distigmine bromide in the treatment of patients with underactive detrusor. Int Urol Nephrol 36, 507–512 (2004). https://doi.org/10.1007/s11255-004-0847-8
Issue Date:
DOI: https://doi.org/10.1007/s11255-004-0847-8