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Histopathological changes and oxidative stress associated with Fascioliasis in bovines

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Abstract

Fascioliasis, a prevalent disease in livestock globally, is primarily caused by the trematode parasites Fasciola hepatica and Fasciola gigantica. This parasitic infection leads to significant economic repercussions. In this study, our objective was to gain insight into the pathophysiological consequences of Fascioliasis in cattle through the evaluation of metabolic, oxidative stress, and histological parameters. A thorough investigation was carried out on the liver of 197 bovines after their slaughter, which unveiled the occurrence of Fascioliasis, with a prevalence rate of 13.2% observed. The bovine that were infected exhibited notable increase in serum transaminases (ALT, AST, and ALP) and malondialdehyde (MDA) and catalase (CAT) while the decrease in glutathione (GSH) and superoxide dismutase (SOD) levels. The lipid profile analysis of infected cattle revealed alterations in the cholesterol and triglyceride levels. Moreover, the histopathological examination revealed a range of hepatic lesions associated with Fascioliasis, including necrosis, inflammation, fibrosis, and proliferative alterations. The bile ducts also displayed distinct pathological changes, including hyperplasia, thickening, and edema, and harbored various developmental stages of Fasciola spp. highlighting the parasitic infestation’s effects on the biliary system. These results highlight the serious effects of Fascioliasis on lipid metabolism and the oxidative damage that is induced in the livers of cattle. Thus, Fasciola infestation in bovine causes alteration in biochemical and antioxidant activities, which are considered as important factors in the diagnosis of Fascioliasis.

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Authors and Affiliations

  1. Department of Animal Medicine (Infectious Diseases), Faculty of Veterinary Medicine, Benha University, Toukh, 13736, Egypt

    Salma A. Shoulah & Abdelfattah Selim

  2. Department of Pathology, Faculty of Veterinary Medicine, Benha University, Toukh, 13736, Egypt

    Mohamed M. S. Gaballa

  3. Department of Parasitology, Faculty of Veterinary Medicine, Benha University, Toukh, 13736, Egypt

    Marwa Mohamdy Al-Assas

  4. General Supervisor of Al-Basateen Abattoir of Cairo Veterinary Authority, Cairo, 4252011, Egypt

    Sayed A. Saqr

  5. Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia

    Hattan S. Gattan

  6. Special Infectious Agents Unit, King Fahad Medical Research Center, King AbdulAziz University, Jeddah, Saudi Arabia

    Hattan S. Gattan

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  1. Salma A. Shoulah
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  2. Mohamed M. S. Gaballa
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  6. Abdelfattah Selim
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Conceptualization, methodology, formal analysis, investigation, resources, data curation, writing – original draft preparation: Salma Shoulah, Mohamed Gaballa, Marwa Al-Assas, Abdelfattah Selim, and Sayed Saqr; writing – review and editing: Salma Shoulah, Mohamed Gaballa, Marwa Al-Assas, Abdelfattah Selim, Hattan Gattan, and Sayed Saqr; project administration: Abdelfattah Selim; funding acquisition: Salma Shoulah, Mohamed Gaballa, Marwa Al-Assas, Abdelfattah Selim, and Sayed Saqr. All authors have read and agreed to the published version of the manuscript.

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Shoulah, S.A., Gaballa, M.M.S., Al-Assas, M.M. et al. Histopathological changes and oxidative stress associated with Fascioliasis in bovines. Trop Anim Health Prod 56, 48 (2024). https://doi.org/10.1007/s11250-024-03896-1

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