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DNA binding and antitumor activities of platinum(IV) and zinc(II) complexes with some S-alkyl derivatives of thiosalicylic acid

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Abstract

A series of complexes of platinum(IV) (C1–C5) and zinc(II) (C6–C10) with S-alkyl derivatives of thiosalicylic acid were prepared and characterized. The interactions of the complexes with calf thymus DNA were analyzed by absorption (UV–Vis) and emission spectral studies (ethidium bromide displacement studies). The cytotoxic activities of complexes C1–C10 were determined against mouse B cell lymphocytic leukemia cells (BCL1), human B-prolymphocytic leukemia (JVM-13), mouse mammary carcinoma cells (4T1), and human mammary carcinoma cells (MDA-MB-468) and compared to the activities of the free ligand precursors and cisplatin. The cytotoxicities of the platinum(IV) and zinc(II) complexes toward mouse tumor cell lines were higher compared with their effects on human tumor cell lines. The zinc(II) complex C9 showed the highest antitumor activity toward the tested human cell lines, while the platinum(IV) complex C4 exhibited the highest antitumor activity toward mouse BCL1 and 4T1 cells. Both C4 and C9 have ligands derived from S-propyl thiosalicylic acid.

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Acknowledgements

This work was funded by grants from the Serbian Ministry of Science and Technological Development (Grants Nos. ON175069, ON172016, and ON172011), Serbia, and the Faculty of Medical Sciences, University of Kragujevac (MP 01/14 and MP 02/14).

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Author notes

  1. Zana Besser Silconi and Sasa Benazic contributed equally to this study.

Authors and Affiliations

  1. Department of Cytology, Pula General Hospital, Pula, Croatia

    Zana Besser Silconi

  2. Department of Transfusiology, Pula General Hospital, Pula, Croatia

    Sasa Benazic

  3. Department for Histology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia

    Jelena Milovanovic

  4. Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia

    Milena Jurisevic, Dragana Djordjevic, Milos Nikolic, Marina Mijajlovic & Gordana Radić

  5. Department of Chemistry, Faculty of Science, University of Kragujevac, Kragujevac, Serbia

    Zoran Ratkovic, Snezana Radisavljevic & Biljana Petrovic

  6. Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia

    Jelena Milovanovic, Milena Jurisevic, Dragana Djordjevic, Gordana Radosavljevic, Marija Milovanovic & Nebojsa Arsenijevic

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  1. Zana Besser Silconi
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  2. Sasa Benazic
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Correspondence to Marija Milovanovic or Nebojsa Arsenijevic.

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Besser Silconi, Z., Benazic, S., Milovanovic, J. et al. DNA binding and antitumor activities of platinum(IV) and zinc(II) complexes with some S-alkyl derivatives of thiosalicylic acid. Transit Met Chem 43, 719–729 (2018). https://doi.org/10.1007/s11243-018-0260-2

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