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Synthesis, characterization and biological studies of CoII, NiII, CuII and ZnII complexes of Schiff bases derived from 4-substituted carbostyrils[quinolin2(1H)-ones]

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Abstract

Schiff bases derived from 4-aminomethylcarbostyril and their transition metal complexes with CoII, NiII, CuII and ZnII have been synthesized and characterized by elemental analysis, molar conductance, magnetic susceptibilities electronic, IR, PMR, ESR, FAB-Mass and thermal studies. From the above spectral studies it is concluded that the ligands of 4-substituted carbostyril Schiff bases, viz, salicylidene 4-aminomethylcarbostyril (SAMC); o-vanillinsalicylidene 4-aminomethylcarbostyril (VAMC) and 5′ chlorosalicylidene 4-aminomethylcarbostyril (CSAMC) act as bidenate molecules coordinating through azomethine nitrogen and phenolic oxygen. The ligands and their metal complexes have been screened in vitro for antibacterial, antifungal and antitumor activity. The results indicate that the biological activity increases on complexation. The CuII complexes of the above ligands show greater inhibitory action towards the P388/s tumor cells at lower concentrations.

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Authors and Affiliations

  1. Division of Inorganic Chemistry, Department of Chemistry, Karnatak University’s Karnatak Science College, Dharwad, Karnataka, 580001, India

    M. A. Phaniband & S. D. Dhumwad

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  1. M. A. Phaniband
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  2. S. D. Dhumwad
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Correspondence to S. D. Dhumwad.

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Phaniband, M.A., Dhumwad, S.D. Synthesis, characterization and biological studies of CoII, NiII, CuII and ZnII complexes of Schiff bases derived from 4-substituted carbostyrils[quinolin2(1H)-ones]. Transition Met Chem 32, 1117–1125 (2007). https://doi.org/10.1007/s11243-007-0295-2

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