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Thrombosis of sinus sagitalis during puerperium caused by thrombophilic gene mutation

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Abstract

Cerebral veno-sinus thrombosis (CVT) during puerperium may have fatal consequences. A nonspecific clinical picture must be complete with computed tomography of the brain and digital substract angiography of the brain blood vessels, and, once the clinical diagnosis is confirmed, coagulation tests and genetic analysis of the coagulation factor are to be made as well. Genetic polymorphisms associated with thrombophilia such as factor V Leiden, prothrombin G20210A, MTHFR C677T, ACE and PIA1/A2 may be the cause of the hypercoagulability that results in CVT.

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Authors and Affiliations

  1. Department of Neurology, Split University Hospital, Spinčićeva 1, Split, 21 000, Croatia

    Marina Titlic & Sanda Pavelin

  2. Department of Internal medicine, Split University Hospital, Spinčićeva 1, Split, 21 000, Croatia

    Ante Tonkic & Ivana Jukic

  3. Department of Radiology, Split University Hospital, Spinčićeva 1, Split, 21 000, Croatia

    Ante Buca

  4. Department of Pathology and Forensic Medicine, Split University Hospital, Spinčićeva 1, Split , 21 000, Croatia

    Simun Andelinovic

Authors
  1. Marina Titlic
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  2. Sanda Pavelin
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  3. Ante Tonkic
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  4. Ivana Jukic
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  5. Ante Buca
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  6. Simun Andelinovic
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Correspondence to Marina Titlic.

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Titlic, M., Pavelin, S., Tonkic, A. et al. Thrombosis of sinus sagitalis during puerperium caused by thrombophilic gene mutation. J Thromb Thrombolysis 25, 270–272 (2008). https://doi.org/10.1007/s11239-007-0061-5

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  • DOI: https://doi.org/10.1007/s11239-007-0061-5

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