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Unusual case of aortic valve involvement in patient with Löffler’s Endomyocarditis: management, follow-up and short review of the literature

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Abstract

Idiopathic hypereosinophilic syndrome (IHES) is an uncommon systemic disease which is characterised by blood eosinophilia and multiple clinical presentations. Cardiac involvement is the major cause of mortality and morbidity. Here we describe a 59-year-old man with symptoms of progressive dyspnea on exertion, and productive cough as an unusual case of Löffler endomyocarditis with a mass on the aortic valve which showed regression with treatment.

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References

  1. Dauphin C, Motreff P, Ruivard M, Rieu V, Cloix JJ, Lamaison D, Cassagnes J, Lusson JR (2005) Regressive aortic valve and infundibular tumors during idiopathic hypereosinophilic syndrome. J Am Soc Echocardiogr 18(7):772a

    Article  Google Scholar 

  2. Loffler W (1936) Endocarditis parietalis fibroplastica mit bluteosinophilie. Ein eigenartiges Krankheitsbild. Schweiz Med Wochenschr 66:817–820

    Google Scholar 

  3. Weller P, Bubley G (1994) The idiopathic hypereosinophilic syndrome. Blood 83(10):2759–2779

    PubMed  CAS  Google Scholar 

  4. Parrillo JE, Borer JS, Henry WL, Wolff SM, Fauci AS (1979) The cardiovascular manifestations of the hypereosinophilic syndrome. Prospective study of 26 patients with review of the literature. Am J Med 67(4):572–582

    Article  PubMed  CAS  Google Scholar 

  5. Shah RS, Ananthasubramaniam K (2006) Evaluation of cardiac involvement in hypereosinophilic syndrome: complementary roles of transthoracic, transesopageal, and contrast echocardiography. Echocardiography 23(8):689–691

    Article  PubMed  Google Scholar 

  6. Gudmundsson GS, Ohr J, Leya F, Jacops WR, Godwin JE, Schwartz J (2003) An unusual case of recurrent Loffler endomyocarditis of the aortic valve. Arch Pathol Lab Med 127(5):606–609

    PubMed  Google Scholar 

  7. Hendren WG, Jones EL, Smith MD (1988) Aortic and mitral valve replacement in idiopathic hypereosinophilic syndrome. Ann Thorac Surg 46:570–571

    Article  PubMed  CAS  Google Scholar 

  8. Smith MD, Metcalfe M, DeMaria AN, Hendren WG, Walter PF, Jones EL (1989) Hypereosinophilic syndrome resulting in aortic and mitral stenosis: a case requiring double valve replacement. Am Heart J 117(2):475–479

    Article  PubMed  CAS  Google Scholar 

  9. Fauci AS, Harley JB, Roberts WC, Ferrans VJ, Gralnick HR, Bjornson BH (1982) NIH conference. The idiopathic hypereosinophilic syndrome Clinical pathophysiologic and therapeutic considerations. Ann Intern Med 97(1):78–92

    PubMed  CAS  Google Scholar 

  10. Assa’ad AH, Spicer RL, Nelson DP, Zimmermann N, Rothenberg ME (2000) Hypereosinophilic syndromes. Chem Immunol 76:208–229

    Article  PubMed  CAS  Google Scholar 

  11. Parrillo JE, Fauci AS, Wolff SM (1978) Therapy of the hypereosinophilic syndrome. Ann Intern Med 89:167–172

    PubMed  CAS  Google Scholar 

  12. Cortes J, Ault P, Koller C, Thomas D, Ferrajoli A, Wierda W, Rios MB, Letvak L, Kaled ES, Kantarjian H (2003) Efficacy of imatinib mesylate in the treatment of idiopathic hypereosinophilic syndrome. Blood 101:4714–4716

    Article  PubMed  CAS  Google Scholar 

  13. Anghel G, De rosa L, Ruscio C, Petti N, Riccardi M, Severino A, Majolino I (2005) Efficay of imatinib mesylate in a patient with idiopathic hypereosinophilic syndrome and severe involvement. Tumori 91(1):67–70

    PubMed  Google Scholar 

  14. Radford DJ, Garlick RB, Pohlner PG (2002) Multiple valvar replacements for hypereosinophilic syndrome. Cardiol Young 12(1):67–70

    Article  PubMed  Google Scholar 

  15. Fuzeller JF, Chapoutot L, Torossian PF, Metz D, Baehrel B (2005) Mitral valve replacement in idiopathic eosinophilic endocarditis without peripheral eosinophilia. J Card Surg 20(5):472–474

    Article  Google Scholar 

  16. Mazuecos JB, Alberca PM, Farre J, Orejas M, Fuente A, Prieto E (2006) Early differential resolution of right and left ventricular obliteration in Löffler Endocarditis after chemotherapy and anticoagulation. Circulation 114:e635–e637

    Article  Google Scholar 

  17. Menzel T, Lambertz H, Rau G (1992) Cardiac involvement in the hypereosinophilia syndrome. The importance of echocardiography in the follow-up. Dtsch Med Wochenschr 117(40):1518–1524

    Article  PubMed  CAS  Google Scholar 

  18. Bunc M, Remskar Z, Brucan A (2001) The idiopathic hypereosinophilic syndrome. Eur J Emerg Med 8(4):325–330

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Cardiology, Istanbul University Cerrahpasa School of Medicine, Istanbul, 212, Turkey

    Evin Bozcali, Farid Aliyev, Mustafa Tarik Agac, Hakan Erkan, Barıs Okcun, Erhan Babalik & Hakan Karpuz

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  1. Evin Bozcali
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  2. Farid Aliyev
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  3. Mustafa Tarik Agac
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  4. Hakan Erkan
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  5. Barıs Okcun
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  6. Erhan Babalik
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  7. Hakan Karpuz
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Correspondence to Farid Aliyev.

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Bozcali, E., Aliyev, F., Agac, M.T. et al. Unusual case of aortic valve involvement in patient with Löffler’s Endomyocarditis: management, follow-up and short review of the literature. J Thromb Thrombolysis 24, 309–313 (2007). https://doi.org/10.1007/s11239-007-0029-5

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  • DOI: https://doi.org/10.1007/s11239-007-0029-5

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