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Spray Deposited ZnO Nanograins for Enzyme-Free Detection of Sarcosine

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Abstract

Sarcosine is one of the known small molecule biomarkers to detect prostate cancer effectively. In the present work, we presented a very simple procedure and low-cost non-enzymatic method for the detection of Sarcosine. Zinc oxide (ZnO) nanoparticles were successfully synthesized, characterized and elucidated the morphology on the Indium tin oxide (ITO) surface, which showed uniform arrangement with a spherical shape. The ITO working electrode modified with ZnO exhibits better analytical characteristics for Sarcosine sensing with a linear range between 5 and 100 nM. The limit of detection was found to be low (7.5 nM) with excellent sensitivity and possess quick response time. Due to its high specificity and repeatability, the ITO/ZnO working electrode does not interfere with the other amino acids in the real samples.

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Acknowledgements

The authors wish to acknowledge TRR fund, SASTRA Deemed University, for financial and infrastructural support.

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Authors and Affiliations

  1. Center for Nanotechnology and Advanced Biomaterials, SASTRA Deemed to be University, Thanjavur, Tamilnadu, 613401, India

    Stalin Selvaraj

  2. Functional Nanomaterials lab @School of Electrical & Electronics Engineering, SASTRA Deemed to be University, Thanjavur, Tamilnadu, 613401, India

    K. Sri Varshini, T. Sonia, B. G. Jeyaprakash & D. Balamurugan

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  1. Stalin Selvaraj
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Selvaraj, S., Varshini, K.S., Sonia, T. et al. Spray Deposited ZnO Nanograins for Enzyme-Free Detection of Sarcosine. Sens Imaging 22, 46 (2021). https://doi.org/10.1007/s11220-021-00369-9

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