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A new pharmacological composition based on water-soluble pectin metal complexes stimulating hematopoiesis

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Abstract

New pharmacological compositions based on water-soluble pectin metal complexes PG-NaCaFe and PG-NaFeCoCu (PG is polygalacturonate) in weight ratios of 6: 1, 9: 1, and 12: 1 promising for pharmacology and medicine as drugs for the treatment of both iron deficiency and pernicious anemia are developed. According to the testing results on males of the Sprague Dawley rat line in vivo, the most pronounced increase in the number of erythrocytes and hematocrit is observed upon the introduction of the composition with the 9: 1 PG-NaCaFe to PG-NaFeCoCu weight ratio indicating the highest efficiency of this complex drug.

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Authors and Affiliations

  1. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, 8 ul. Akademika Arbuzova, 420088, Kazan, Russian Federation

    S. T. Minzanova, E. V. Chekunkov, A. V. Khabibullina, A. B. Vyshtakalyuk, K. V. Kholin, L. G. Mironova, G. R. Nizameeva, A. R. Khamatgalimov, I. S. Ryzhkina, L. I. Murtazina & V. A. Milyukov

Authors
  1. S. T. Minzanova
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  2. E. V. Chekunkov
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  3. A. V. Khabibullina
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  4. A. B. Vyshtakalyuk
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  5. K. V. Kholin
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  6. L. G. Mironova
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  7. G. R. Nizameeva
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  8. A. R. Khamatgalimov
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  9. I. S. Ryzhkina
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  10. L. I. Murtazina
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  11. V. A. Milyukov
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Corresponding author

Correspondence to S. T. Minzanova.

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Additional information

The authors are grateful to the Collective Spectral Analytical Center of Physicochemical Investigation of Structure, Properties, and Composition of Substances and Materials of the Kazan Scientific Center (Russian Academy of Sciences) for technical support of the studies.

All procedures involving animals corresponded to the ethical standards of the enterprise at which the studies were carried out and confirmed by legal documents of the RF and international organizations.

Based on the materials of the XII All-Russia Scientific Conference with International Participation and the School of Young Scientists “Chemistry and Technology of Plant Substances” (November 29–December 2, 2022, Kirov, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 9, pp. 2263–2277, September, 2023.

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Minzanova, S.T., Chekunkov, E.V., Khabibullina, A.V. et al. A new pharmacological composition based on water-soluble pectin metal complexes stimulating hematopoiesis. Russ Chem Bull 72, 2263–2277 (2023). https://doi.org/10.1007/s11172-023-4024-6

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  • DOI: https://doi.org/10.1007/s11172-023-4024-6

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