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Preparation of 155Tb-labeled short somatostatin analog

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Abstract

The complex of the short somatostatin analog, DOTA—Phe—D-Trp—Lys—Thr—OMe (DOTA is 1,4,7,10-tetrraazacyclododecane-1,4,7,10-tetraacetic acid), with the theragnostic 155Tb radionuclide was obtained for the first time. The radionuclide was generated in a cyclotron according to the reaction natGd(α,x)155Dy⟶155Tb. The complex was characterized by thin layer chromatography. The in vitro stability was assessed in saline and in the presence of bovine serum. The complex showed a satisfactory stability under these conditions for 24 h.

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Authors and Affiliations

  1. National Research Center, Kurchatov Institute, 1 akad. Kurchatova, 123182, Moscow, Russian Federation

    A. N. Moiseeva, R. A. Aliev & D. S. Khachatryan

  2. Institute of Chemical Reagents and High-Purity Chemical Substances, National Research Center, Kurchatov Institute, 3 Bogorodskii Val, 107076, Moscow, Russian Federation

    V. N. Osipov & D. S. Khachatryan

  3. N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, 24 Kashirskoe shosse, 115522, Moscow, Russian Federation

    V. N. Osipov

Authors
  1. A. N. Moiseeva
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  2. R. A. Aliev
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  3. V. N. Osipov
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  4. D. S. Khachatryan
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Correspondence to A. N. Moiseeva or V. N. Osipov.

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Additional information

The authors are grateful to B. V. Egorova for valuable advice during planning of the experiment.

The production of the 155Tb radionuclide was financially supported by the Ministry of Science and Education of the Russian Federation (agreement No. 075-15-2021-1360). Analytical studies were performed using the research equipment of the Center for Collective Use of the Institute of Chemical Reagents and High-Purity Chemical Substances, National Research Center, Kurchatov Institute, with the financial support of the project from the Ministry of Science and Education of the Russian Federation (agreement No. 075-15-2022-1157 dated August 16, 2022). The study was supported by the National Research Center, Kurchatov Institute (order No. 2751).

No human or animal subjects were used in this research.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 9, pp. 2249—2254, September, 2023.

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Moiseeva, A.N., Aliev, R.A., Osipov, V.N. et al. Preparation of 155Tb-labeled short somatostatin analog. Russ Chem Bull 72, 2249–2254 (2023). https://doi.org/10.1007/s11172-023-4022-8

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  • DOI: https://doi.org/10.1007/s11172-023-4022-8

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