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5-Hydroxy-1-phenylimidazolidine-2-thione as a new amidoalkylating agent for heterocyclic compounds

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Abstract

We showed a possibility of using 5-hydroxy-1-phenylimidazolidine-2-thione as an amidoalkylating agent in the reactions with 1-methyloxindole, 3-pyrazolone, and pyrazole derivatives to obtain a number of new unsymmetric bis-heterocyclic compounds with a direct C-C bond containing a combination of pharmacophoric groups of two classes of heterocycles.

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation

    K. A. Kochetkov, O. N. Gorunova & N. A. Bystrova

Authors
  1. K. A. Kochetkov
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  2. O. N. Gorunova
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  3. N. A. Bystrova
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Corresponding author

Correspondence to K. A. Kochetkov.

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The authors declare no competing interests.

Additional information

This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation using the equipment of the Center for Molecular Structure Studies at the A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences.

No human or animal subjects were used in this research.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 587–590, March, 2022.

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Kochetkov, K.A., Gorunova, O.N. & Bystrova, N.A. 5-Hydroxy-1-phenylimidazolidine-2-thione as a new amidoalkylating agent for heterocyclic compounds. Russ Chem Bull 71, 587–590 (2022). https://doi.org/10.1007/s11172-022-3454-x

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  • DOI: https://doi.org/10.1007/s11172-022-3454-x

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