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2-(Germatran-1-yloxy)ethylamine as an inhibitor of the total activity of mononuclear alkaline phospholipase A2

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Abstract

The previously unknown ability of 2-(germatran-1-yloxy)ethylamine to affect the activity of alkaline phospholipase A2 was studied. Daily administration of an aqueous solution of 2-(germatran-1-yloxy)ethylamine for 2 months in an active substance dose of 10 mg per kg of animal body weight resulted in inhibition of the total activity of the alkaline phospholipase A2 of mononuclear cells. The results of the study can be used to correct the lipid metabolism in the development of hyperlipidemic disorders. This may extend the scope of applicability of the studied compound and lead to development of new pharmacological agents based on 2-(germatran-1-yloxy)ethylamine for the prevention and suppression of hyperlipidemias.

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Authors and Affiliations

  1. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 119334, Moscow, Russian Federation

    I. V. Zhigacheva

  2. Irkutsk National Research Technical University, 83 ul. Lermontova, 665074, Irkutsk, Russian Federation

    V. P. Baryshok

  3. State Scientific Research Institute of Chemistry and Technology of Organoelement Compounds, 38 sh. Entuziastov, 105118, Moscow, Russian Federation

    M. M. Rasulov & P. A. Storozhenko

Authors
  1. I. V. Zhigacheva
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  2. V. P. Baryshok
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  3. M. M. Rasulov
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  4. P. A. Storozhenko
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Corresponding authors

Correspondence to I. V. Zhigacheva, V. P. Baryshok or M. M. Rasulov.

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The authors declare no competing interest.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 444–448, March, 2021.

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Zhigacheva, I.V., Baryshok, V.P., Rasulov, M.M. et al. 2-(Germatran-1-yloxy)ethylamine as an inhibitor of the total activity of mononuclear alkaline phospholipase A2. Russ Chem Bull 70, 444–448 (2021). https://doi.org/10.1007/s11172-021-3106-6

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  • DOI: https://doi.org/10.1007/s11172-021-3106-6

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