Abstract
The rate of sorption and desorption of cinchomeronic and dipicolinic acids on the AB-17-8 strongly basic anion exchanger is limited by slow diffusion of components in the polymer phase. The diffusion coefficient of the organic anion in the phase of the AB-17-8 anion exchanger is equal to (3.7±0.5)•10–12 m2 s–1. Taking into account high rates of desorption of anions of cinchomeronic and dipicolinic acids from anionite (the half-transformation time is 6 min), the AB-17-8 strongly basic anion exchanger can be recommended for use as a container for development of prolonged drugs based on pyridinedicarboxylic acids.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1927–1930, October, 2018.
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Altshuler, H.N., Shkurenko, G.Y. & Altshuler, O.H. Anion exchange kinetics with participation of cinchomeronic and dipicolinic acids. Russ Chem Bull 67, 1927–1930 (2018). https://doi.org/10.1007/s11172-018-2309-y
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DOI: https://doi.org/10.1007/s11172-018-2309-y