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Synthesis of new acridine-9-carboxylic acid derivatives

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Abstract

New 1,3-dihydroxyacridine-9-carboxylic acids were obtained by Pfitzinger reaction from 2,4,6-trihydroxytoluene (methylphloroglucinol). Their bromination and azo-coupling reactions were studied. Computer simulation was used to determine potential pharmacokinetic and toxic properties of the synthesized compounds.

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References

  1. A. B. Oliveira, M. F. Dolabela, F. C. Braga, R. L. R. P. Jácome, F. P. Varotti, M. M. Póvoa, An. Acad. Bras. Cienc., 2009, 81, 715.

    Article  Google Scholar 

  2. T. N. Kudryavtseva, A. Yu. Lamanov, L. G. Klimova, G. V. Nazarov, Russ. Chem. Bull., 2017, 66, 123.

    Article  CAS  Google Scholar 

  3. S. S. Bobylev, K. I. Kobrakov, D. N. Kuznetsov, A. G. Ruchkina, S. A. Shevelev, A. Kh. Shakhnes, A. N. Fakhrutdinov, Russ. Chem. Bull., 2015, 64, 154.

    Article  CAS  Google Scholar 

  4. S. S. Bobylev, D. N. Kuznetsov, K. I. Kobrakov, A. G. Ruchkina, A. N. Fakhrutdinov, Russ. J. Org. Chem., 2015, 51, 1572.

    Article  CAS  Google Scholar 

  5. M.-G. A. Shvekhgeymer, O. A. Moreva, Dokl. Akad. Nauk, 2000, 372, 778

    Google Scholar 

  6. M.-G. A. Shvekhgeymer, O. A. Moreva, [Dokl. Chem. (Engl. Transl.), 2000, 382].

  7. Molinspiration Cheminformatics Slovak Republic, URL: http://www.molinspiration.com/cgi-bin/properties (date of application 19.05.2017).

  8. C. A. Lipinski, F. Lombardo, B. W. Dominy, P. Feeney, Adv. Drug. Deliv. Rev., 1997, 23, 3.

    Article  Google Scholar 

  9. Institute of Biomedical Chemistry, URL: http://www.pharmaexpert.ru/PASSOnline/(date of application 21.02.2015).

  10. Institute of Biomedical Chemistry.–URL: http://www.way2drug.com/gusar/acutoxpredict.html (date of application 19.05.2017).

  11. A. V. El’tsov, Laboratornyi praktikum po sintezu promezhutochnykh produktov i krasitelei. Uchebnoe posobie dlya vuzov [Laboratory Manual on the Synthesis of Intermediate Products and Dyes. Textbook for High Schools], Khimiya, Leningrad, 1985, 352 pp. (in Russian).

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Authors and Affiliations

  1. А. N. Kosygin Russian State University “Technologies. Design. Art”, Chair of Organic Chemistry, 1 ul. Malaya Kaluzhskaya, 119991, Moscow, Russian Federation

    V. V. Melyshenkova, D. N. Kuznetsov, A. G. Ruchkina & K. I. Kobrakov

Authors
  1. V. V. Melyshenkova
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  2. D. N. Kuznetsov
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  3. A. G. Ruchkina
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  4. K. I. Kobrakov
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Corresponding author

Correspondence to D. N. Kuznetsov.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 0878–0883, May, 2018.

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Melyshenkova, V.V., Kuznetsov, D.N., Ruchkina, A.G. et al. Synthesis of new acridine-9-carboxylic acid derivatives. Russ Chem Bull 67, 878–883 (2018). https://doi.org/10.1007/s11172-018-2152-1

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  • DOI: https://doi.org/10.1007/s11172-018-2152-1

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