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Nitrobenzoxadiazole derivatives as nitric oxide donors: ESR study using spin trapping

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Abstract

The ability of nitrobenzoxadiazoles to induce the SOX-operon from a genetically engineered biosensor based on E. coli MG 1655 (pSoxS-lux) was confirmed by the fact of producing nitric oxide. The NO-donating properties of three nitrobenzoxadiazole derivatives bearing π-excessive carbo- and heterocycles were found by the ESR method using spin trapping. The yield of nitrogen(II) oxide was 17, 0.3, and 1.6%. Sodium sulfide accelerates the thiol-dependent transformation and increases the yield of nitric oxide to 27, 16, and 12%, respectively.

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Authors and Affiliations

  1. N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 109991, Moscow, Russian Federation

    V. A. Serezhenkov & N. A. Tkachev

  2. Southern Federal University, 194/1 prosp. Stachki, 344090, Rostov-on-Don, Russian Federation

    Yu. P. Semenyuk, S. V. Kurbatov, E. Yu. Kharchenko & V. A. Chistyakov

Authors
  1. V. A. Serezhenkov
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  2. N. A. Tkachev
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  3. Yu. P. Semenyuk
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  4. S. V. Kurbatov
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  5. E. Yu. Kharchenko
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  6. V. A. Chistyakov
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Correspondence to V. A. Serezhenkov.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 0076—0082, January, 2017.

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Serezhenkov, V.A., Tkachev, N.A., Semenyuk, Y.P. et al. Nitrobenzoxadiazole derivatives as nitric oxide donors: ESR study using spin trapping. Russ Chem Bull 66, 76–82 (2017). https://doi.org/10.1007/s11172-017-1702-2

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  • DOI: https://doi.org/10.1007/s11172-017-1702-2

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