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Drug design based on the carbon/silicon switch strategy

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Russian Chemical Bulletin Aims and scope

Abstract

Classical bioisosteric substitution is the replacement of a carbon atom by a silicon atom (sila-substitution, carbon/silicon switch). The review is focused on the effects of bioisosteric carbon/silicon switch on the activity of the known pharmaceuticals. In the majority of cases, silicon derivatives show enhanced biological activities and improved pharmacological profiles as compared with the parent carbon drug scaffolds.

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  1. A. E. Favorsky Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 ul. Favorskogo, 664033, Irkutsk, Russian Federation

    N. F. Lazareva & I. M. Lazarev

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  1. N. F. Lazareva
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1221–1232, June, 2015.

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Lazareva, N.F., Lazarev, I.M. Drug design based on the carbon/silicon switch strategy. Russ Chem Bull 64, 1221–1232 (2015). https://doi.org/10.1007/s11172-015-1005-4

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