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Antiarrhythmic agents based on diterpenoid alkaloids

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Abstract

Diterpenoid alkaloids comprise a large group of natural compounds produced by the plants of the genera Aconitum and Delphinium. Some of these compounds were found to manifest valuable pharmacological properties, including the unique antiarrhythmic activity. Allapinine (derived from the alkaloid lappaconitine) was approved as a drug. The investigation of the structure—activity relationship revealed structural elements responsible for the arrhythmogenic and antiarrhythmic properties.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Ufa Scientific Center of the Russian Academy of Sciences, 71 prosp. Oktyabrya, 450075, Ufa, Russian Federation

    M. S. Yunusov

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  1. M. S. Yunusov
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Correspondence to M. S. Yunusov.

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Based on the materials of the lecture delivered on the Session of the Presidium of the Russian Academy fo Sciences on February 8, 2011.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 620–624, April, 2011.

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Yunusov, M.S. Antiarrhythmic agents based on diterpenoid alkaloids. Russ Chem Bull 60, 633–638 (2011). https://doi.org/10.1007/s11172-011-0098-7

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  • DOI: https://doi.org/10.1007/s11172-011-0098-7

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