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Acylation of Meldrum’s acid with arylacetic acid imidazolides as a convenient method for the synthesis of 4-aryl-3-oxobutanoates

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Abstract

C-Acylation of Meldrum’s acid by (het)arylacetic acids in ethanol in the presence of 1,1′-carbonyldiimidazole leads to ethyl 4-(het)aryl-3-oxobutanoates in high yields.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    A. A. Shimkin, V. Z. Shirinian, A. K. Mailian, D. V. Lonshakov, V. V. Gorokhov & M. M. Krayushkin

Authors
  1. A. A. Shimkin
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  2. V. Z. Shirinian
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  3. A. K. Mailian
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  4. D. V. Lonshakov
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  5. V. V. Gorokhov
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  6. M. M. Krayushkin
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Correspondence to A. A. Shimkin.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 134–136, January, 2011.

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Shimkin, A.A., Shirinian, V.Z., Mailian, A.K. et al. Acylation of Meldrum’s acid with arylacetic acid imidazolides as a convenient method for the synthesis of 4-aryl-3-oxobutanoates. Russ Chem Bull 60, 139–142 (2011). https://doi.org/10.1007/s11172-011-0019-9

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  • DOI: https://doi.org/10.1007/s11172-011-0019-9

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