Abstract
1-[4-Aminoarylpyrazolo[3,4-b]pyridin-5-yl]pyridinium chlorides undergo cyclization under reflux in tert-butanol in the presence of an excess of potassium tert-butoxide to form tetracyclic derivatives of pyrazolo[3,4-b]pyrido[1′,2′:1,2]imidazo[4,5-d]pyridine. The reaction scheme of the processes is proposed. The structures of the reaction products were confirmed by physicochemical methods.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
V. G. Granik, in Osnovy meditsinskoi khimii [Fundamentals of Medical Chemistry], Vuzovskaya kniga, Moscow, 2001, p. 192 (in Russian).
X. Q. Xiao, R. Wang, and X. C. Tang, J. Neurosci. Res., 2000, 61, 564.
S. Yoshida and N. Suzuki, Eur. J. Pharmacol., 1993, 250, 117.
F. A. Davis, D. Stefoski, and F. N. Quandt, Ann. Neurol., 1995, 37, 684.
C. Reidlinger, R. Dworczak, H. Junek, and H. Graubaum, Monatsh. Chem., 1998, 129, 1313.
F. A. Harden, R. J. Quinn, and P. J. Scammells, J. Med. Chem., 1991, 34, 2892.
K. Gewald, M. Rehwald, H. Müeller, and P. Bellmann, Liebigs Ann. Org. Bioorg. Chem., 1995, 5, 787.
K. Gewald, H. Schäfer, P. Bellman, and H. Müeller, Chem. Ber., 1991, 124, 1237.
N. A. Rastorgueva, S. Yu. Ryabova, E. A. Lisitsa, L. M. Alekseeva, and V. G. Granik, Izv. Akad. Nauk, Ser. Khim., 2003, 2036 [Russ. Chem. Bull., Int. Ed., 2003, 52, 1386].
Author information
Authors and Affiliations
Additional information
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 710–714, April, 2006.
Rights and permissions
About this article
Cite this article
Komarova, E.S., Makarov, V.A., Alekseeva, L.M. et al. Synthesis of derivatives of a new heterocyclic system pyrazolo[3,4-b]pyrido[1′,2′: 1,2]imidazo[4,5-d]pyridine. Russ Chem Bull 55, 735–740 (2006). https://doi.org/10.1007/s11172-006-0322-z
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/s11172-006-0322-z