Abstract
Acylation of cis,trans,cis-PtIV(RNH2)(NH3)(OH)2Cl2 with acetic anhydride afforded complexes cis,trans,cis-PtIV(RNH2)(NH3)(OAc)2Cl2, where R is 2,2,6,6-tetramethyl-1-oxylpiperidin-4-yl (1b) or 2,2,5,5-tetramethyl-1-oxylpyrrolidin-3-yl (2b). The complexes were characterized by elemental analysis, HPLC, and IR, UV, and ESR spectra. Complex 1b exhibits high antitumor activity comparable with that of Cisplatin against leukemia P388 used as the experimental tumor. Simultaneous administration of low doses of 1b and Cisplatin (1/20 of LD50 each) results in synergism of the antitumor activity and 100% cure of animals.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 60–63, January, 2006.
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Sen’, V.D., Golubev, V.A., Lugovskaya, N.Y. et al. Synthesis and antitumor properties of new platinum(IV) complexes with aminonitroxyl radicals. Russ Chem Bull 55, 62–65 (2006). https://doi.org/10.1007/s11172-006-0215-1
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DOI: https://doi.org/10.1007/s11172-006-0215-1