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Ultrasound-based synthesis of ZnO·Ag2O3 nanocomposite: characterization and evaluation of its antimicrobial and anticancer properties

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Abstract

In this research, a facile method using ultrasound waves was used to synthesize the ZnO·Ag2 nanocomposite. It was completely characterized by powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), dynamic light scattering (DLS) and zeta potential. PXRD showed the synthesis of ZnO and Ag2O3 in hexagonal and orthorhombic crystal structure. Microscopic images confirmed the formation of cubic, hexagonal, rectangular and spherical morphologies. The DLS size analysis showed that the mean dynamic size of the nanocomposite was 100.5 nm. Agar diffusion method was used for antimicrobial test and the results showed high antibacterial activity of ZnO·Ag2O3 nanocomposite against two major classes of pathogenic bacteria (i.e., Escherichia coli, Klebsiella pneumonia, Staphylococcus epidermidis and Staphylococcus aureus). Anticancer properties of ZnO·Ag2O3 nanocomposite using MTT assay showed that ZnO·Ag2O3 nanocomposite is toxic for human liver cancer cell line (HepG2). This effect depends on time and concentration of ZnO·Ag2O3 nanocomposite. The cell toxicity effects of ZnO·Ag2O3 nanocomposite also examined against HDF normal cell, in which the data demonstrated the lower cytotoxicity of nanocomposite compared to the HepG2 cell line. These results support the potential application of ZnO·Ag2O3 nanocomposites in antimicrobial agents, liver carcinoma treatments and also merit future translational research.

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Abbreviations

PXRD:

Powder X-ray diffraction

FESEM:

Field emission scanning electron microscopy

TEM:

Transmission electron microscopy

DLS:

Dynamic light scattering

NMP:

N-Methyl-2-pyrrolidone

MTT:

3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

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Acknowledgements

The authors appreciatively acknowledge for support and assistance provided by Mashhad University of Medical Sciences (Grant No. 981595).

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Authors and Affiliations

  1. Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Mohammad Ehsan Taghavizadeh Yazdi, Fahimeh Nourbakhsh & Seyed Hadi Mousavi

  2. Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Mohammad Mashreghi

  3. Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Seyed Hadi Mousavi

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  1. Mohammad Ehsan Taghavizadeh Yazdi
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Taghavizadeh Yazdi, M.E., Nourbakhsh, F., Mashreghi, M. et al. Ultrasound-based synthesis of ZnO·Ag2O3 nanocomposite: characterization and evaluation of its antimicrobial and anticancer properties. Res Chem Intermed 47, 1285–1296 (2021). https://doi.org/10.1007/s11164-020-04355-w

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