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Aerobic oxidative synthesis of benzimidazoles from amines catalyzed by 3-methyl-4-oxa-5-azahomoadamantane and iron(III) chloride

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Abstract

A simple and efficient catalytic system including 3-methyl-4-oxa-5-azahomoadamantane and FeCl3 for aerobic oxidative synthesis of benzimidazoles from primary amines and o-phenylenediamine is presented. This process uses O2 as economic and green oxidant and water as green solvent, tolerates a wide range of substrates, and can afford the target products in moderate to excellent yields.

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  1. Chemical Engineering College, Nanjing University of Science and Technology, Nanjing, 210094, China

    Jiatao Yu & Ming Lu

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  1. Jiatao Yu
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  2. Ming Lu
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Correspondence to Ming Lu.

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Yu, J., Lu, M. Aerobic oxidative synthesis of benzimidazoles from amines catalyzed by 3-methyl-4-oxa-5-azahomoadamantane and iron(III) chloride. Res Chem Intermed 41, 10017–10025 (2015). https://doi.org/10.1007/s11164-015-2009-2

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  • DOI: https://doi.org/10.1007/s11164-015-2009-2

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