Abstract
The cross-aldol condensation between isatin (I) and substituted acetophenone (IIa–e) in one-pot reaction afforded 3-[2-(substituted-phenyl)-2-oxo-ethylidene]-1,3-dihydro-indol-2-one using polyethylene glycol (PEG-400) as solvent and bleaching earth clay (pH 12.5) as a catalyst at room temperature. The PEG 400, bleaching earth are recyclable green solvent and catalyst, respectively. The formed compounds were confirmed by spectral analysis. These compounds show significant antimicrobial activity.
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Acknowledgments
Authors are grateful to UGC SAP Award No (F.3-36/2011) (SAP-II). A.P.A. is grateful to UGC for a teacher fellowship under their FDP scheme. R.D.K. and S.D.P. are grateful to CSIR, New Delhi for JRF. The authors gratefully acknowledge the Director, School of chemical Sciences SRTMU, IICT and Vishnu chemicals, Hyderabad for spectral analysis.
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Acharya, A.P., Kamble, R.D., Patil, S.D. et al. Green method for synthesis of 3-[2-(substituted-phenyl)-2-oxo ethylidene]-1,3-dihydro-indol-2-one and their in vitro antimicrobial activity. Res Chem Intermed 41, 2953–2959 (2015). https://doi.org/10.1007/s11164-013-1403-x
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DOI: https://doi.org/10.1007/s11164-013-1403-x