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Efficient solvent-free synthesis of tertiary propargylic alcohols from arylacetylenes and ketones promoted by tert-BuOK

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Abstract

A mild and efficient method for the alkynylation of arylacetylenes with ketones promoted by tert-BuOK under solvent-free conditions was developed. The present green synthesis was applicable to many kinds of aromatic and aliphatic ketones providing good to excellent yields of tertiary propargylic alcohols.

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A mild and efficient method for the alkynylation of arylacetylenes with ketones promoted by tert-BuOK under solvent-free conditions was developed. The present green synthesis was applicable to many kinds of aromatic and aliphatic ketones providing good to excellent yields of tertiary propargylic alcohols.

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Acknowledgments

The project is generously supported by National Natural Science Foundation of China (Nos. 20902044 and 21102068), Natural Science Foundation of Inner Mongolia of China (No. 2009BS0204) and “Chunhui” Program from Ministry of Education of China (Z2009-1-01003).

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  1. College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, China

    Shufeng Chen, Fang Yuan, Haiying Zhao & Baoguo Li

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  1. Shufeng Chen
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  2. Fang Yuan
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  3. Haiying Zhao
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  4. Baoguo Li
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Correspondence to Baoguo Li.

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Chen, S., Yuan, F., Zhao, H. et al. Efficient solvent-free synthesis of tertiary propargylic alcohols from arylacetylenes and ketones promoted by tert-BuOK. Res Chem Intermed 39, 2391–2399 (2013). https://doi.org/10.1007/s11164-012-0765-9

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