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Preparation and structures of some new 1H-pyrazole derivatives

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Abstract

Some new 3,5-diaryl-1H-pyrazoles were prepared from aryl methyl ketones via Claisen condensation with aromatic esters and followed by cyclization with hydrazine monohydrate. Their structures were confirmed by IR, 1H NMR spectroscopy, mass spectrometry and elemental analysis. The X-ray structure for 3(5)-(4-tert-butylphenyl)-5(3)-(4-methoxyphenyl)-1H-pyrazole (2b) was presented. The results show that compound 2b exists as tautomers I and II, and its molecules are connected by the N–H···N intermolecular hydrogen bonds to form cyclic dimers consisting of the tautomers I and II.

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Acknowledgment

This work was supported by the important Foundation of the Educational Commission of Hubei Province PR China (no. CXY2009B029).

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Authors and Affiliations

  1. Hubei Key Laboratory of Pollutant and Reuse Technology, College of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi, 435002, China

    Dun-Jia Wang, Yan-Fang Kang, Chun-Yang Zheng & Xian-Hong Wei

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  1. Dun-Jia Wang
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  2. Yan-Fang Kang
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Correspondence to Dun-Jia Wang.

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Wang, DJ., Kang, YF., Zheng, CY. et al. Preparation and structures of some new 1H-pyrazole derivatives. Res Chem Intermed 39, 2311–2320 (2013). https://doi.org/10.1007/s11164-012-0758-8

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  • DOI: https://doi.org/10.1007/s11164-012-0758-8

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