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An efficient and facile synthesis of novel substituted pyrimidine derivatives: 4-amino-5-carbonitrile-2-nitroaminopyrimidine

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Abstract

One-pot, multicomponent reaction for the synthesis of novel substituted pyrimidine derivatives: 4-amino-5-carbonitrile-2-nitroaminopyrimidine from aromatic aldehydes, 1-nitroguanidine, and malononitrile under ethanol is described. Because of containing many active functional groups, such as amino, cyan and nitro, these products are important intermediate of organic synthesis. The advantages of this procedure include the short reaction time, mild reaction conditions, and excellent yields.

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Acknowledgments

We are grateful to the National Natural Science Foundation of China (NSFC) (21172188), the Foundation of Jiangsu Normal University (10XLS02) and Priority Academic Program Development of Jiangsu Higher Education Institutions for financial support.

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Authors and Affiliations

  1. Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, College of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, 221116, Jiangsu, People’s Republic of China

    Sheng Xia, Shan Yin, Shimin Tao, Yanhui Shi & Liangce Rong

  2. School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou, 221006, Jiangsu, People’s Republic of China

    Liangce Rong, Xianyong Wei & Zhimin Zong

Authors
  1. Sheng Xia
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  2. Shan Yin
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  3. Shimin Tao
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  4. Yanhui Shi
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  5. Liangce Rong
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  6. Xianyong Wei
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  7. Zhimin Zong
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Correspondence to Liangce Rong.

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Xia, S., Yin, S., Tao, S. et al. An efficient and facile synthesis of novel substituted pyrimidine derivatives: 4-amino-5-carbonitrile-2-nitroaminopyrimidine. Res Chem Intermed 38, 2435–2442 (2012). https://doi.org/10.1007/s11164-012-0559-0

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  • DOI: https://doi.org/10.1007/s11164-012-0559-0

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