Skip to main content
SpringerLink
Log in

Synthesis and characterization of ramose tetralactosyl-lysyl-chitosan-5-fluorouracil and its in vitro release

  • Published:
Research on Chemical Intermediates Aims and scope Submit manuscript

Abstract

In order to improve drug loading and achieve a good release effect, this paper adopts the ramose method, choosing chitosan as the carrier and 5-fluorouracil (5-Fu) as a model drug. Ramose chitosan-lysyl-5-Fu(3) and ramose tetralactosyl-lysyl-chitosan-5-Fu(6) were synthesized successfully, then the in vitro release of (6) was researched. The results show that the drug loading of (3) and (6) are 9.17 and 1.63% (w/w), respectively. The in vitro release behavior of (6) in pH 7.4 phosphate buffer solution and pH 1.2 HCl–KCl solution were studied. The zero order release time that (6) maintains in alkaline and acidic media are 64 and 24 h, and the total release by 184 h are 71.97 and 82.34%, respectively. The performance is smooth throughout the whole stage of release, and the concentration of cumulative release is lower in the alkaline environment than in the acidic environment over the same time.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1

Similar content being viewed by others

References

  1. P. Caliceti, S. Salmaso, S. Bersani, in Macromolecular anticancer therapeutics, cancer drug discovery and development, ed. by L.H. Reddy, P. Couvreur (Springer, Berlin, 2010), pp. 163–219

    Google Scholar 

  2. E. Lee, J. Lee, I.H. Lee, M. Yu, H. Kim, S.Y. Chae, S. Jon, J. Med. Chem. 51(20), 6442–6449 (2008)

    Article  CAS  Google Scholar 

  3. P. Zhao, H. Wang, M. Yu, S. Cao, F. Zhang, J. Chang, R. Niu, Pharm. Res. 27, 1914–1926 (2010)

    Article  CAS  Google Scholar 

  4. W. Yang, T. Mou, W. Guo, H. Jing, C. Peng, X. Zhang, Y. Ma, B. Liu, Bioorg. Med. Chem. Lett 20, 4840–4844 (2010)

    Article  CAS  Google Scholar 

  5. K. Bezouška, Rev. Mol. Biotechnol. 90(3–4), 269–290 (2002)

    Article  Google Scholar 

  6. T. Fukuda, S. Onogi, Y. Miura, Thin Solid Films 518(2), 880–888 (2009)

    Article  CAS  Google Scholar 

  7. P. Chi, J. Wang, C.S. Liu, Mater. Lett. 62, 147–150 (2008)

    Article  CAS  Google Scholar 

  8. K.W. Yang, X.R. Li, Z.L. Yang, P.Z. Li, F. Wang, Y. Liu, J. Biomed. Mater. Res. A 88, 140–148 (2009)

    Google Scholar 

  9. L. Kosynkina, G.K. Wang, L.T. Chyan, Tetrahedron Lett. 35(29), 5173–5176 (1994)

    Article  CAS  Google Scholar 

  10. S. Pichlmair, M. de Lera Ruiz, K. Basu, L.A. Paquette, Tetrahedron 62(22), 5178–5194 (2006)

    Article  CAS  Google Scholar 

  11. P. Agrawal, U. Gupta, N.K. Jain, Biomaterials 28(22), 3349–3359 (2007)

    Article  CAS  Google Scholar 

  12. H. Feng, C.M. Dong, Carbohydr. Polym. 70(3), 258–264 (2007)

    Article  CAS  Google Scholar 

  13. D. Liu, C. Liu, W. Zou, N. Zhang, Nanopart Res 12, 975–984 (2010)

    Article  CAS  Google Scholar 

  14. S.V. Chankeshwara, A.K. Chakraborti, Organic Lett 8(15), 3259–3262 (2006)

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 20775010), the Natural Science Foundation of Hunan Province of China (06JJ2038) and the Graduate Innovation Fund of Hunan Province of China.

Author information

Authors and Affiliations

  1. College of Chemical and Biologic Engineering, Changsha University of Science and Technology, Changsha, 410004, China

    He-ping Li, Long Qin, Zhou-dong Wang & Shan Li

Authors
  1. He-ping Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Long Qin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zhou-dong Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shan Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to He-ping Li.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, Hp., Qin, L., Wang, Zd. et al. Synthesis and characterization of ramose tetralactosyl-lysyl-chitosan-5-fluorouracil and its in vitro release. Res Chem Intermed 38, 1421–1429 (2012). https://doi.org/10.1007/s11164-011-0473-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11164-011-0473-x

Keywords

Search

Navigation